Systematic evaluation of the effectiveness and safety of GanShuang Granules combined with entecavir in the treatment of hepatitis B cirrhosis
Objective To systematically evaluate the effectiveness and safety of GanShuang Granules combined with entecavir in improving patients with hepatitis B cirrhosis.Methods Computer-based searches were conducted in PubMed,CNKI,Wanfang Data,VIP,and other databases to retrieve clinical randomized controlled trials on the treatment of chronic hepatitis B cirrhosis with GanShuang Granules combined with entecavir.Two evaluators independently assessed the methodological quality of the included studies,and Meta-analysis was performed using RevMan 5.3 software.Results A total of 25 articles were included.The results of the Meta-analysis showed that the combination of GanShuang Granules and entecavir in the treatment of hepatitis B cirrho-sis was superior to entecavir alone in terms of HBeAg clearance rate[OR(95％CI)=3.08(1.84,5.16),P＜0.01],HBVP DNA[MD(95％CI)=-0.97(-1.38,-0.55),P＜0.01)],liver function indicators such as ALT[MD(95％CI)=-21.14(-28.38,-13.9),P＜0.01],AST[MD(95％CI)=-2.1(-2.51,-1.69),P＜0.01],ALB[MD(95％CI)=5.23(4.47,6.00),P＜0.01],TBIL[MD(95％CI)=-10.75(-12.45,-9.05),P＜0.01],and liver fibrosis indicators such as HA[MD(95％CI)=-40.68(-48.39,-32.97),P＜0.01],LN[MD(95％CI)=-27.11(-31.99,-22.24,P＜0.01],PC-Ⅲ[MD(95％CI)=-29.06(-32.64,-25.49)],P＜0.01],Ⅳ-C[MD(95％CI)=-27.74(-28.88,-19.64),P＜0.01]and other aspects were better than that of Entecavir treatment.The differences were statistically significant(P＜0.05).There was no signifi-cant differ-ence in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combi-nation of GanShuang Granules and entecavir is significantly more effective than Entecavir alone in the treatment of chronic hepatitis B cirrhosis.
Gan Shuang GranulesEntecavirHepatitis BLiver cirrhosisMeta-analysis
NETL
NSTL
万方数据
