Effects of Gongwaiyun Prescription combined with methotrexate and mifepristone on β-HCG and CK levels in patients with tubal pregnancy
Objective To analyze the effects of Gongwaiyun Prescription combined with methotrexate+mifepristone on beta human chorionic gonadotropin(β-HCG)and creatine kinase(CK)levels in patients with tubal pregnancy.Methods A total of 126 patients with tubal pregnancy admitted to Ninghai County Maternal and Child Health Hospital from January 2022 to December 2023 were selected and randomly divided into an observation group(63 cases)and a control group(63 cases)according to whether they were treated with Gongwaiyun Prescription or not.The observation group was treated with Gongwaiyun prescription combined with methotrexate and mifepristone,while the control group was treated with methotrexate and mifepristone alone.Statistical analysis was conducted on the clinical efficacy,serum β-HCG and CK levels,the time for serum β-HCG to return to normal and the disappearance of mass,as well as adverse reaction between the two groups.Results The total effective rates of the observation group and the control group were 94％and 76％,respectively,and the difference was statistically significant(x2=4.771,P=0.021).Both serum β-HCG and CK levels significantly decreased after treatment in both groups(P＜0.001).The serum β-HCG and CK levels in the observation group at 4 d,7 d,and 14 d after treatment were significantly lower than those in the control group,and the differences were statistically significant(t=6.117,7.462,14.001,2.996,3.402,7.569,all P＜0.001).The recovery time of serum β-HCG and the time for mass disappearance in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(t=4.417,7.122,all P＜0.001).The total incidence of adverse reactions in the observation group was 49％,while that in the control group was 81％,and the difference was statistically significant(x2=5.779,P=0.018).Conclusion The combined use of Gongwaiyun prescription combined with methotrexate and mifepristone is more conducive to improving the serum β-HCG and CK levels of patients with tubal pregnancy,shortening the time for serum β-HCG to turn negative and the disappearance of mass,reducing the incidence of adverse reactions,and achieving more significant overall efficacy.Therefore,it is worthy of clinical promotion and application.
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