Clinical efficacy and immune function of different doses of interferon α-2b aerosol inhalation in the treat-ment of viral pneumonia in children
Objective To investigate the clinical efficacy and impact on immune function of different doses of interferon α-2b nebulized inhalation therapy for children with viral pneumonia.Methods A total of 90 children with viral pneumonia treated in People's Hospital of Sheqi County from January 2022 to December 2023 were selected and divided into a low dose group,a high dose group and a control group according to different treatment,30 cases per group.The control group received conventional treatment,the low-dose group received low-dose interferon α-2b treatment on the basis of the same treatment as the control group,and the high-dose group received high-dose interferon α-2b treatment on the basis of the same treatment as the control group.The clinical efficacy,immune function,inflammatory factors,disappearance time of clinical symptoms,and adverse re-actions of the three groups were compared.Results The total effective rate of the high-dose and low-dose groups was higher than that of the control group.After treatment with interferon α-2b,the CD4+and CD4+/CD8+levels in the high-dose and low-dose groups were higher than those in the control group,while CD8+levels were lower than those in the control group;the CD4+and CD4+/CD8+levels in the high-dose group were higher than those in the low-dose group,while CD8+levels were lower than those in the low-dose group;the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)in the high-dose and low-dose groups were lower than those in the control group;the levels of CRP.TNF-α,and IL-6 in the high-dose group were lower than those in the low-dose group;the disappearance time of lung rales,wheezing,coughing,and fever in the high-dose and low-dose groups was shorter than that in the control group;the disappearance time of lung rales,wheezing,coughing,and fever in the high-dose group was shorter than that in the low-dose group,with statistical differences(P＜0.05).There was no statistically significant difference in the total effective rate between the high-dose group and the low-dose group(P＞0.05);there was no statistically significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).Conclusion The treatment of interferon α-2b can improve the immune func-tion,reduce the level of inflammatory factors,without the adverse effects,and the effect of α-2b is better.
NETL
NSTL
万方数据
