Effects of Wuji Baifeng Pill combined with venlafaxine on ApoB and miR-195 in patients with postpartum depression
Objective To analyze the effects of Wuji Baifeng Pill combined with venlafaxine on ApoB and miR-195 in patients with postpartum depression(PPD).Methods A total of 150 patients with postpartum depression treated in the Wenzhou Seventh People's Hospital from July 2022 to June 2023 were selected.All pa-tients were divided into a control group(75 cases)and a study group(75 cases)by random number table method.The control group was treated with venlafaxine,while the study group was treated with Wuji Baifeng Pill com-bined with venlafaxine.The levels of ApoB,5-hydroxytryptamine(5-HT),norepinephrine(NE),sex hormones,miR-195,miR-124,Pittsburgh Sleep Quality Index(PSQI),and Edinburgh Postnatal Depression Scale(EPDS)scores were measured in both groups.The clinical efficacy and adverse reactions of the two groups were com-pared.Results Compared with before treatment,the levels of ApoB,P,miR-124,PSQI scores,and EPDS scores in both groups decreased after treatment,and the study group was lower than the control group after treatment(P＜0.05).Compared with before treatment,the levels of 5-HT,NE,E2,and miR-195 in both groups increased af-ter treatment,and in the study group was higher than the control group after treatment(P＜0.05).Compared with the control group,the patients in the study group showed higher overall treatment effectiveness after treatment(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Wuji Baifeng Pill combined with venlafaxine can effectively alleviate patients'anxiety,en-hance their sleep quality,and improve their overall quality of life,demonstrating a notable therapeutic outcome.
Wu Ji Bai Feng WanVenlafaxine hydrochlorideDepression,postpartumApolipopro-teinsGonadal steroid hormones
NETL
NSTL
万方数据
