Effects of Tongqiao Biyan Granules combined with bacterial lysates capsule on small airway function and airway inflammatory response in patients with allergic rhinitis
Objective To explore the effects of Tongqiao Biyan Granule combined with bacterial lysates capsule on small airway function and airway inflammatory response in patients with allergic rhinitis(AR).Methods A total of 120 clinical data of patients with AR admitted to Jinhua Maternal and Child Health Hospi-tal from June 2022 to June 2023 were selected for the study.According to the different treatment methods,they were divided into a conventional group(treated with bacterial lysates capsule,n=60)and a combination group(treated with Tongqiao Biyan Granules combined with bacterial lysates capsule,n=60),with a treatment period of one month for both groups.The treatment effects,traditional Chinese medicine(TCM)syndrome scores,small air-way function[maximal mid-expiratory flow(MMEF),forced expiratory flow at 50％(FEF50),forced expiratory flow at 75％(FEF75)],airway inflammatory response[fractional exhaled nitric oxide(FeNO),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],serum cytokines[interleukin-4(IL-4),interleukin-6(IL-6),interleukin-17(IL-17)],and incidence of adverse reactions were compared between the two groups.Results The effective rate in the combination group was significantly higher than that in the conventional group(95.0％vs 81.7％,x2=5.175,P＜0.05).After treatment,the TCM syn-drome scores of nasal congestion,nasal itching,and runny nose in the combi-nation group[(1.4±0.4)points,(1.5±0.6)points,(1.4±0.5)points,respectively]were significantly lower than those in the control group[(2.5±0.8)points,(2.6±0.6)points,and(2.6±0.6)points](t=9.947,10.563,10.906,all P＜0.05);The levels of small airway function indicators,including MMEF,FEF50,and FEF75,in the combination group[(2.2±0.4)L/s,(2.42±0.33)L/s,(1.29±0.17)Us,respectively]were significantly higher than those in the conven-tional group[(1.9±0.3)L/s,(2.17±0.27)Us,(1.07±0.14)Us,respectively](t=5.301,4.542,7.738,all P＜0.05).The levels of airway inflammatory markers,including FeNO,CRP,and TNF-α,in the combination group[(14±4)ppb,(16±4)ng/ml,(7.6±1.8)ng/ml]were significantly lower than those in the conventional group[(16±4)ppb,(20±4)ng/mL,(10.5±2.2)ng/mL,respectively](t=3.623,6.796,7.733,all P＜0.05).The serum levels of cytokines IL-4,IL-6,and IL-17 in the combination group[(5.7±0.9)ng/L.(94±20)ng/L,(32.6±4.8)ng/L]were significantly lower than those in the conventional group[(8.3±1.1)ng/L,(125±22)ng/L,(43.5±5.4)ng/L,respectively](t=14.392,8.346,11.798,all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the combination group(3.3％)and the conventional group(8.3％)(x2=1.365,P＞0.05).Conclusion The combination of Tongqiao Biyan Granules and bacterial lysates capsule has a significant therapeutic effect on pa-tients with AR,which can improve the traditional Chinese medicine syndrome scores and small airway function of patients,and reduce airway inflammation.
Rhinitis,allergicTong Qiao Bi Yan PianPentoprilSmall airway functionInflammatory
NETL
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