Therapeutic effect of Xuefu Zhuyu and Xuanyin Decoction on pleural thickening in patients with tubercu-lous pleurisy
Objective To observe the effect of Xuefu Zhuyu and Xuanyin Decoction on pleural thickening and therapeutic effect in patients with tuberculous pleurisy(TP).Methods A retrospective analysis was conduct-ed on a total of 93 TP patients admitted to Xinchang County People's Hospital from February 2019 to January 2023.The patients were divided into a traditional Chinese and Western medicine group(n=47)and a control group(n=46)by treatment methods.The control group was treated with anti-tuberculosis short-course chemotherapy regi-men(2HRZE/4HR),while the traditional Chinese and Western medicine group was treated with Xuefu Zhuyu and Xuanyin Decoction in addition to the treatment given to the control group,with a treatment period of two months for both groups.The traditional Chinese medicine(TCM)syndrome scores,drainage volume,pleural effusion ab-sorption time,pleural thickness,and serum inflammatory factor levels were compared between the two groups,and the clinical efficacy and safety of the two groups were evaluated.Results After treatment,the scores of main and secondary symptoms in TCM and the total scores of both groups were lower than those before treatment,and the scores of the traditional Chinese and Western medicine group were lower than those of the control group(t=2.745,P=0.007;t=4.667,P＜0.01;t=4.776,P＜0.01).Compared with the control group,the traditional Chinese and West-ern medicine group showed a reduction in drainage volume(t=11.790,P＜0.0 1)and a shortened time for ascites ab-sorption(t=2.152,P=0.034).The pleural thickness in both the traditional Chinese and Western medicine group and the control group was significantly thicker before treatment compared to 1 month after treatment(t=5.426,9.504,all P＜0.01)and 2 months after treatment(t=3.090,P=0.003;t=7.679,P＜0.01).Furthermore,the pleural thickness in both groups at 2 months after treatment was significantly thinner than that at 1 month(t=2.480,P=0.015;t=2.260,P=0.026).After 1 month and 2 months of treatment,the pleural thickness in the traditional Chi-nese and Western medicine group was significantly thinner than that in the control group(t=4.904,5.607,all P＜0.01).After treatment,the serum levels of interferon-gamma(INF-γ)and interleukin-6(IL-6)in both groups were reduced compared to those before treatment,and the levels in the integrated traditional Chinese and Western medicine group were lower than those in the control group(t=12.740,t=5.251,all P＜0.01).The total effective rate in the traditional Chinese and Western medicine group was significantly higher than that in the control group(93.6％vs 78.3％,x2=4.559,P=0.033).The total incidence of adverse reactions in the traditional Chinese and Western medicine group and the control group was 25.5％and 21.7％respectively,and there was no statistically significant difference between the two groups(x2=0.185,P=0.667).Conclusion The combination of Xuefu Zhuyu and Xuanyin Decoction and short-course anti-tuberculosis chemotherapy can effectively prevent pleural thicke ning,promote pleural effusion absorption,inhibit inflammatory response,and has high safety in the treatment of TP.
Pleurisy,tuberculousXue Fu Zhu Yu TangPleuraComparative effectiveness research
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