Effects of Danzhi Xiaoyao Powder combined with leuprolide acetate on the secondary sexual characteris-tics,bone age development,and safety in girls with idiopathic central precocious puberty
Objective To explore the effects of Danzhi Xiaoyao Powder combined with leuprorelin on the development of secondary sexual characteristics and bone age in girls with idiopathic central precocious puberty(ICPP).Methods A total of 196 female children with ICPP who received outpatient treatment in Ninghai County Maternal and Child Health Hospital from January 2020 to December 2023 were selected as a retrospective study cohort and divided into an observation group(104 cases)and a control group(92 cases).The observation group received Danzhi Xiaoyao Powder combined with leuprolide acetate treatment,while the control group received leuprolide acetate treatment alone.The secondary sexual characteristics indicators(breast development score,ovarian volume),sex hormone indicators[luteinizing hormone(LH),follicle-stimulating hormone(FSH),and estradiol(E2)],bone age,predicted final adult height(FAH),25-hydroxyvitamin D3(25-OH-D3),and adverse reaction data of the two groups were statistically analyzed.Results After 6 and 12 months of treatment,the breast nucleus area,uterine volume,and ovarian volume of both groups significantly decreased(P＜0.001).However,the breast nucleus area,uterine volume,and ovarian volume of the observation group were significantly smaller than those of the con-trol group,and the differences were statistically significant(t=7.319,2.951,3.901,all P＜0.01).After 6 and 12 months of treatment,the levels of LH,FSH,and E2 in both groups were significantly reduced(P＜0.01),but the levels of LH,FSH,and E2 in the observation group were significantly lower than those in the control group,and the difference was statistically significant(t=3.007,4.952,9.911,all P＜0.01).After 6 and 12 months of treatment,bone age growth was significantly suppressed in both groups(P＜0.05),and the predicted FAH was sig-nificantly improved(P＜0.001).However,the observation group had significantly better bone age and predicted FAH than the control group,and the difference was statistically significant(t=2.361,3.209,P=0.017,0.001).The levels of 25-OH-D3 significantly increased in both groups after treatment(P＜0.001),and there was a statistically significant dif-ference in the levels of 25-OH-D3 between the two groups after treatment(t=8.316,P＜0.001).The total incidence of adverse reactions in the observation group and the control group was 14.4％and 51.1％,respectively,with a statistically significant difference(x2=7.931,P=0.009).Conclusions Danzhi Xiaoyao Powder combined with leuprelin is more beneficial to improve the secondary sexual characteristics and optimizing bone age development in female children with ICPP,and is worthy of clinical promotion and application.
Puberty,precociousJia Wei Xiao Yao SanLeuprolideSex characteristicsAge de-termination by skeleton
NETL
NSTL
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