子宫动脉栓塞联合甲氨蝶呤及宫孕方对瘢痕妊娠患者清宫术出血情况β-人绒毛膜促性腺激素及月经恢复时间的影响
Effects of uterine artery embolization combined with methotrexate and uterine pregnancy formula on bleeding during curettage,β-HCG recovery time,and menstrual recovery time in patients with scarred pregnancy
张秀萍 1徐菲菲 1张琳 1潘莎莎1
作者信息
- 1. 宁海县第一医院妇产科,浙江宁波 315600
- 折叠
摘要
目的 探讨子宫动脉栓塞术(UAE)联合甲氨蝶呤及宫孕方对剖宫产瘢痕妊娠(CSP)清宫术出血量、β-人绒毛膜促性腺激素(β-HCG)水平及月经恢复正常时间的影响.方法 选取浙江省宁海县第一医院2018年1月至2021年1月收治的66例CSP患者,收集其基线资料,按治疗方法将患者分为2组,其中29例行UAE+清宫术+甲氨蝶呤+宫孕方(观察组),37例行UAE+清宫术(对照组).统计分析2组围术期指标、β-HCG水平与月经恢复正常时间以及不良反应发生率.结果 66例CSP患者年龄(34±4)岁,β-HCG水平(25 125±3 784)U/L、月经恢复时间(3.8±0.8)个月.观察组患者住院时间、术中出血量及阴道出血持续时间均少于对照组(P＜0.05).观察组患者血清β-HCG水平恢复正常时间和月经恢复正常时间均短于对照组(P＜0.05).观察组不良反应总发生率为10％,对照组不良反应总发生率为16％,差异无统计学意义(P＞0.05).结论 子宫动脉栓塞联合甲氨蝶呤及宫孕方可有效减少CSP患者清宫术出血量,缩短β-HCG水平恢复正常时间和月经恢复正常时间,值得临床推广应用.
Abstract
Objective To investigate the effects of uterine artery embolization(UAE)combined with methotrexate and uterine pregnancy formula on the amount of bleeding,β-human chorionic gonadotropin(β-HCG)levels,and menstrual recovery time during cesarean section scar pregnancy(CSP)curettage.Methods A total of 66 CSP patients admitted to the First Hospital of Ninghai County from January 2018 to January 2021 were select-ed,and their baseline data were collected.The patients were divided into an observation group(29 cases,under-going UAE+curettage surgery+methotrexate+uterine pregnancy formula)and a control group(37 cases,undergo-ing UAE+curettage surgery)depending on treatment methods.The perioperative indicators,β-HCG levels,men-strual recovery time,and incidence of adverse reactions of the two groups were statistically analyzed.Results The age of 66 CSP patients was(34±4)years old,with HCG levels of(25 125±3 784)U/L and menstrual recovery time of(3.8±0.8)months.The hospitalization time,intraoperative bleeding volume,and duration of vaginal bleeding in the observation group were significantly less than those in the control group(P＜0.05).The recovery time of serum β-HCG levels and menstrual cycle in the observation group was significantly shorter than that in the control group(P＜0.05).The total incidence of adverse reactions in the observation group and the control group was 10％and 16％,respectively,with no statistically significant difference(P＞0.05).Conclusion The combination of methotrexate and uterine pregnancy formula can effectively reduce the amount of bleeding during curettage in CSP patients,shorten the time for β-HCG levels to return to normal and menstrual recovery time,and is worthy of clini-cal promotion and application.
关键词
妊娠/子宫动脉栓塞术/刮宫术/人绒毛膜促性腺激素Key words
Pregnancy/Uterine artery embolization/Dilatation and curettage/Chorionic gonadotropin引用本文复制引用
出版年
2024
NETL
NSTL
万方数据