Effects of Huanglian Wendan Decoction combined with Jin's Three-Needle Therapy on gastrointestinal hormones and serum COX-2 and NF-κB in patients with bile reflux gastritis
Objective To explore the effects of Huanglian Wendan Decoction combined with Jin's Three-Needle Therapy on gastrointestinal hormones and serum cyclooxygenase(COX-2)and nuclear factor-KB(NF-κB)in patients with bile reflux gastritis.Methods A total of 112 patients with bile reflux gastritis who attended San-menxia Hospital of Traditional Chinese Medicine in Henan Province from June 2022 to June 2023.All the pa-tients were divided into a control group(56 cases,treated with hydrotalcite chewable tablets)and a study group(56 cases,treated with Huanglian Wendan Decoction combined with Jin's Three-Needle Therapy on the basis of the control group's treatment plan)according to random number table method.Both groups received a one-month treatment.The traditional Chinese medicine syndrome scores,gastrointestinal hormone levels,and serum levels of COX-2 and NF-κB were compared between the two groups before and after treatment.The patients in both groups were followed up for six months to compare the recurrence rates.Results After treatment,the syndrome scores of epigastric pain and belching of the two groups were both decreased compared with before treatment,and the scores of the study group were lower than those of the control group(both P＜0.05);the levels of gastrointestinal hormone-related indicators of the two groups were both increased compared with before treatment,and the levels of the study group were higher than those of the control group(both P＜0.05);the levels of serum COX-2 and NF-κB of the two groups were both decreased compared with before treatment,and the levels of the study group were low-er than those of the control group(both P＜0.05).There were 2 cases of recurrence in the control group,with a re-currence rate of 3.6％,and no recurrence in the study group,and there was no statistically significant difference in the recurrence rate between the two groups(P＞0.05).Conclusion The application of Huanglian Wendan Decoc-tion combined with Jin's Three-Needle Therapy in patients with bile reflux gastritis can effectively alleviate clini-cal symptoms,regulate gastrointestinal hormones,and reduce gastric inflammatory reactions.
Huang Lian Wen Dan TangAcupuncture moxibustion therapyBile refluxGastritisGastrointestinal hormonesCyclooxygenase 2Nuclear factor-KB
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