Relationship between antidepressants and respiratory adverse events in patients with chronic obstructive pulmonary disease
Objective To study the relationship between antidepressants and pulmonary related adverse events(PRAE)in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 242 COPD patients admit-ted to the Second People's Hospital of Lishui,from January 2020 to April 2024 were selected.The clinical data of these patients and their antidepressant use were collected.All patients were divided into a PRAE group(104 cases)and a non-PRAE group(138 cases)according to whether PRAE occurred.The relationship be-tween antide-pressants and PRAE in COPD patients was analyzed using multivariate binary Logistic regression model.Results The PRAE group was compared with the non PRAE group in terms of age,use of antidepressants,duration of an-tidepressant use,presence of respiratory virus infection,presence of Mycoplasma infection,FEV 1％pred,and C-reactive protein,the difference was statistically significant(t/x2=3.870,7.744,8.039,4.454,4.162,-8.397 and 3.254,all P＜0.05).Using PRAE occurrence as a dependent variable,after adjusting confounding fac-tors using a multivariate binary logistic regression model,the results showed that antidepressant use and antide-pressant use duration were independent risk factors for PRAE(OR=2.018,1.383,both P＜0.05).Using the occur-rence of pneu-monia and acute exacerbation as dependent variables respectively,and adjusting for confounding factors such as age,respiratory virus infection,and mycoplasma infection through a multivariate binary logistic re-gression model,the results showed that antidepressant use and duration of antidepressant use remained indepen-dent risk factors for pneumonia and acute exacerbation of COPD(OR=1.910,1.446 and 2.246,1.514,all P＜0.05).Conclusion Antidepressants are associated with an increased risk of pneumonia and acute exacerbation in COPD,close monitor-ing of side effects from antidepressant prescriptions is necessary,and consideration should be given to non-phar-macological interventions.
万方数据
维普
