Short-term efficacy and safety of different doses of urokinase in the treatment of deep venous thrombosis of lower extremities after coronary intervention in patients with coronary heart disease
Objective To analyze the short-term efficacy and safety of different doses of urokinase in the treatment of deep venous thrombosis of lower extremities after coronary intervention in patients with coronary heart disease.Methods A total of 80 patients with deep venous thrombosis of lower extremities after coronary interven-sion treated with urokinase catheter thrombolysis in the Third People's Hospital of Henan Province were selected as the study subjects.They were divided into group A and group B according to treatment methods,with 40 cases in each group.The dose of urokinase in group A was 1 million U/d,and the dose of urokinase in group B was 500 000 U/d.The treatment lasted for 7 days,and the patients were followed up for 6 months.The circumference of the affected limbs,serum fibrinogen(FBG),D-dimer(D-D)in different parts before and after treatment were ob-served in the two groups.Thrombolysis rate,detumescence rate,and incidence of adverse reactions were compared between the two groups.According to the growth and decline of venous thrombosis in the affected limbs and the blood flow in the veins,the clinical efficacy was comprehensively evaluated.Results The circumference of af-fected limbs at 5 cm above the ankle,10 cm below the knee,and 10cm above the knee in group A were all smaller than those in group B(P＜0.05).The levels of serum FBG and D-D in group A after treatment were lower than those in group B(P＜0.05).Both groups of patients were followed up.The thrombolysis rate and detumescence rate in group A were higher than those in group B(P＜0.05).There was no significant difference in the total clini-cal effective rate between the two groups(P＞0.05).The total clinical marked effective rate in group A was higher than that in group B(P＜0.05).No deaths or severe organ bleeding was observed in either group,and the main ad-verse reactions were mild,such as hematochezia,hematuria,and gingival bleeding,which were significantly re-lieved after drug with-drawal.There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The thrombolytic effect of 1 million U/d urokinase in the treatment of deep venous thrombosis of lower extremities after coronary intervention is better than that of 500 thousand U/d,and does not significantly increase the risk of bleeding,which edserves clinical attention.
万方数据
维普
