Effects of vitamin D assisted enoxaparin sodium therapy on serum PLGF D-dimer and pregnancy out-comes in patients with early-onset severe preeclampsia
Objective To analyze the effect of vitamin D supplemented with enoxaparin sodium on serum placental growth factor(PLGF),D-dimer(D-D)and pregnancy outcomes in patients with early onset severe preeclampsia(EOSP).Methods A retrospective analysis was conducted on 78 patients with EOSP treated at the Yongkang Maternal and Child Health Hospital in Zhejiang Provincefrom January 2021 to December 2023.According to the patients'willingness and different treatment drugs,they were divided into a vitamin group and a control group.The vitamin group(n=40)received vitamin D-assisted enoxaparin sodium therapy,while the control group(n=38)only received enoxaparin sodium therapy.The efficacy,clinical indicators(gestational age at delivery,neonatal weight,systolic blood pressure,diastolic blood pressure,24-hour urinary protein),laboratory indicators[PLGF,D-D,25-(OH)D and fibrinogen(FIB)]and pregnancy outcomes were compared between the two groups.Results The treatment efficacy of the vitamin group was superior to that of the control group(P＜0.05).The gestational age at delivery in vitamin group with(32.9±2.6)weeks,which was later than(31.1±2.5)weeks in the control group(P＜0.05).The neonatal weight with(2.7±0.4)kg was heavier than(2.2±0.3)kg in control group,and the systolic blood pressure and diastolic blood pressure with(125±11)mmHg and(99±10)mmHg were lower than(134±12)mmHg and(106±11)mmHg in control group,and the 24-hour urinary protein with(1.3±0.3)g was lower than(2.6±0.5)g in control group(all P＜0.05).After treatment,the levels of serum PLGF and 25-(OH)D with(975±36)ng/L and(30±6)μg/L in vitamin group were higher than(742±33)ng/L and(23±5)μg/L in control group while the levels of D-D and FIB with(2.0±0.4)mg/L and(3.0±0.6)g/L were lower than(2.4±0.6)mg/L and(3.9±0.7)g/L in control group(P＜0.05).The total incidence of adverse pregnancy outcomes in the vitamin group and the control group were 2.5％and 18.42％(P＜0.05).Conclusion Vitamin D supplemented with enoxaparin sodium can effectively up-regulate the serum PLGF level and reduce the D-dimer level in patients with EOSP,with no significant differences in pregnancy outcomes.
万方数据
维普
