Clinical effect of sequential treatment with synthroid combined with enteral nutrition in critically ill pa-tients with ventilator-associated pneumonia
Objective To analyze the effect of the implementation of synthroid combined with sequential enteral nutrition measures in critically ill patients with ventilator-associated pneumonia.Methods A total of 118 patients with critically ill ventilator-associated pneumonia admitted to Anyang City Cancer Hospital from August 2021 to February 2024 were divided into a control group(59 cases)and a experimental group(59 cases)by the randomized numerical table method.The control group implemented sequential enteral nutrition therapy,and the experimental group implemented synthroid combined sequential enteral nutrition therapy.The nutritional status in-dicators(gastrointestinal function score,transferrin,albumin,prealbumin),autoimmune status(CD4+,CD8+,CD3+,CD4+/CD8+),inflammatory factors(procalcitonin,C-reactive protein),and health scores of the two groups before treatment and 2 weeks after treatment were compared,as well as the occurrence of diarrhea,abdominal distension,and reflux during treatment.Results Gastrointestinal function scores of patients in the 2 groups were lower after 2 weeks of treatment than before treatment,and the experi-mental group was lower than the control group(t=16.043,P＜0.05);transferrin,albumin,and pre-albumin levels were higher than before treatment,and the experi-mental group was higher than the control group(t=2.578,6.798,and 4.335,all P＜0.05).After 2 weeks of treat-ment,the patients in the 2 groups had higher levels of CD4+,CD3+,CD4+/CD8+were higher than before treatment,and the experimental group was higher than the control group(t=7.332,2.176,4.471,all P＜0.05);CD8+was lower than before treatment,and the experimental group was lower than the control group(t=3.511,P＜0.05).After 2 weeks of treatment,the levels of procalcitonin,C-reactive protein,and acute physiological and chronic health scores of the two groups of patients decreased compared to before treatment,and the experimental group was lower than the control group(t=8.221,11.768,7.266,all P＜0.05).There was no statistically significant difference in the incidence of diarrhea,abdominal distension,and esophageal reflux between the two groups of patients during treat-ment(x2=0.619,P＞0.05).Conclusion Hapten combined with sequential enteral nutrition measures can adjust the nutritional status and gastrointestinal function of patients with ventilator-associated pneumonia in critically ill patients,enhance immunity,reduce inflammation in the patient's body,and restore the patient's health,with good safety.
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