Influencing factors on prognosis of patients with acute respiratory distress syndrome treated with sivelestat sodium
Objective To investigate the efficacy and prognostic factors of sivelestat sodium in the treat-ment of acute respiratory distress syndrome (ARDS). Methods A total of 160 ARDS patients admitted to Daxing District People's Hospital in Beijing from April 2020 to March 2022 were divided into a control group and an ob-servation group based on different treatment plans,with 80 cases in each group. The control group received con-ventional treatment,while the observation group received sivelestat sodium in addition to the same treatment as the control group. The changes in arterial partial pressure of oxygen (PaO2),partial pressure of carbon dioxide (PaCO2),oxygenation index (PaO2/FiO2),and serum levels of C-reactive protein (CRP) and procalcitonin (PCT) were com-pared between the two groups. The factors affecting the prognosis of ARDS treated with sivelestat sodium were an-alyzed using Logistic regression. Results After treatment,the levels of PaCO2,CRP and PCT in the observation group were significantly lower than those in the control group,while PaO2 and PaO2/FiO2 were significantly higher than those in the control group (P<0.05). The proportion of dead patients aged>60 years old and baseline A-PACHE Ⅱ score in observation group were higher than those in survival patients,the time between onset and ad-mission was longer than that in survival patients,and the volume distribution width of red blood cells (RDW) was larger than that in survival patients (P<0.05). Logistic regression analysis showed that age,PEEP level,baseline APACHE Ⅱscore,onset time to hospital admission and RDW level were correlated with the prognosis of ARDS treated with cilvelestat sodium (P<0.05). Conclusion Sivelestat sodium can effectively reduce inflammation and improve blood gas indicators in the treatment of ARDS,but still has a high risk of poor prognosis. Its influencing factors include age,time from onset to admission,baseline APACHE Ⅱ score,RDW level,etc. Actively monitoring these indica-tors has important guiding value for improving the success rate of ARDS treatment and prognosis improvement.
Respiratory distress syndromeSivelestat sodiumRoot cause analysis
万方数据
维普
