Effects of butylphthalide combined with aspirin on cognitive function and serum levels of ET-1 and TXB2 in patients with first-episode lacunar infarcts
Objective To explore the effects of butyphthalide combined with aspirin on cognitive function,severity of neurological impairment,cerebral hemodynamics parameters,serum endothelin-1 (ET-1) and thrombox-ane B2 (TXB2) in patients with first-episode lacunar infarcts (LI). Methods A total of 97 patients with first-episode LI in Lishui People's Hospital were retrospectively enrolled between February 2021 and February 2024. According to different treatment methods,they were divided into a control group (47 cases,aspirin) and a butyph-thalide group (50 cases,butyphthalide combined with aspirin). Before and after treatment,severity of neurological impairment[National Institutes of Health Stroke Scale (NIHSS)],cognitive function[mini-mental state examination (MMSE),Montreal Cognitive Assessment Scale (MoCA)],serum ET-1,TXB2 and cerebral hemodynamics parame-ters in the two groups were compared. The total response rate of treatment (reduction rate of NIHSS) and incidence of adverse reactions were calculated. Results After treatment,total response rate in butyphthalide group was higher than that in control group (P<0.05). After 14d of treatment,NIHSS score in butyphthalide group was lower than that in control group (P<0.05),MMSE and MoCA scores were higher than those in control group (P<0.05). The levels of serum ET-1 and TXB2,peak velocity and difference value of peak velocity in butyphthalide group were higher than those in control group (P<0.05),while mean velocity was slower than that in control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups ( P>0.05). Conclusion Butyphthalide combined with aspirin can improve total response rate of treatment,repair nerve func-tion injury,improve cognitive function,regulate serum ET-1,TXB2 and cerebral blood flow perfusion in patients with first-episode LI,and has good safety.
万方数据
维普
