Efficacy of granulocyte colony-stimulating factor in promoting endometrial repair after intrauterine adhesion separation surgery
Objective To explore the clinical efficacy of intrauterine infusion of granulocyte colony-stimulating factor (G-CSF) in promoting endometrial repair after hysteroscopic adhesions for moderate to severe intrauterine adhesions. Methods A retrospective analysis was conducted on the clinical data of 58 patients who underwent hysteroscopic adhesions for moderate to severe intrauterine adhesions at Hebei Maternity Hospital from June 2021 to December 2023. All the patients were divided into a G-CSF group (35 cases) and a control group (23 cases) based on whether G-CSF was used postoperatively. The endometrial thickness,menstrual improvement,adhesion recurrence,and pregnancy outcomes before and after surgery were compared between the two groups. Results ①The endometrial thickness of both groups after surgery increased compared to before surgery ( P<0.01),and the endometrial thickness of patients in the G-CSF group after surgery was thicker than that of the control group[(7.14±1.45) mm vs (6.08±2.13) mm],with a statistically significant difference (P<0.05). ②The postoperative menstrual improvement in the G-CSF group was better than that in the control group (91.4％ vs 65.2％),and the difference was statistically significant (P<0.05);There was no statistically significant difference in adhesion recurrence between the two groups (P>0.05). ③ The fertility analysis results were limited to two groups,with pregnancy rates of 37.1％ in the G-CSF group and 26.1％ in the control group;There was no statistically significant difference in the cumulative pregnancy rate between the two groups (P=0.127). The median duration from surgery to conception in the G-CSF group was 11 months 95％CI (8.8,13.1),while in the control group it was 19 months 95％CI (19.7,22.5). Conclusion Intrauterine infusion of G-CSF assisted hysteroscopic adhesions for the treatment of moderate to severe intrauterine adhesions can promote postoperative endometrial repair,increase endometrial thickness and menstrual flow,without reducing the recurrence rate of intrauterine adhesions.
万方数据
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