Effects of Liver-Sparing and Spleen-Strengthening Formula combined with levothyroxine sodium in the treatment of Hashimoto's thyroiditis combined with hypothyroidism
Objective To analyze the effects of Liver-Sparing and Spleen-Strengthening Formula com-bined with levothyroxine sodium on the treatment of patients with Hashimoto's thyroiditis combined with hypothy-roidism.Methods A total of 80 patients with Hashimoto's thyroiditis complicated with hypothyroidism admitted to the Endocrinology and Metabolism Department of Zhengzhou Ninth People's Hospital from January 2022 to October 2023 were divided into a control group (40 cases) and a study group (40 cases) according to treatment methods.The patients in the control group were treated with levothyroxine sodium,and the patients in the study group were treated with Liver-Sparing and Spleen-Strengthening Formula combined with levothyroxine sodium,and the treatment time was 3 months.Compare the treatment effects,serum inflammatory factors[tumor necrosis factor-alpha (TNF-α),interleukin-6 (IL-6),interleukin-12 (IL-12),interferon-gamma (IFN-γ)],thyroid related factors[thyroid-stimulating hormone (TSH),free tri-iodothyronine (FT3),free tetra-iodothyronine (FT4)],lymphocyte subset factors (CD4+,CD8+,CD4+/CD8+,CD3+),and adverse reactions during the treatment process between two groups of patients before and after treatment.Results After treatment,there were 32 effective patients (80.0％) in the control group and 39 effective patients (97.5％) in the study group,and the study group was more effective than the control group.Compared with before treatment,the levels of serum TNF-α,IL-6,IL-12,IFN-γ,TSH,and CD8+of patients in both groups decreased after treatment;Compared to the control group,the above indicators in the study group were lower.Compared with before treatment,the levels of serum FT3 and FT4,as well as CD4+,CD3+,CD4+/CD8+increased in both groups of patients after treatment;Compared to the control group,the above indica-tors in the study group were higher (P<0.05).Conclusion The treatment of Hashimoto's thyroiditis combined with hypothyroidism with Liver-Sparing and Spleen-Strengthening Formula combined with levothyroxine sodium can further enhance the therapeutic efficacy,alleviate the secretion of inflammatory factors in the body,improve the function of the thyroid gland,and regulate the subpopulation of the patient's T-lymphocytes,with a better safety.
Hashimoto diseaseHypothyroidismDispersing stagnated liver Qi and Strengthening spleenThyroxineLymphocytes
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