Effects of low-molecular-weight heparin combined with magnesium sulfate and intravenous nutrition on fetal growth restriction
Objective To analyze the effects of low-molecular-weight heparin combined with magnesium sulfate and intravenous nutrition on fetal growth restriction (FGR).Methods A retrospective analysis was con-ducted on a total of 145 pregnant women with fetal growth restriction (FGR) admitted to Hangzhou Fuyang Women and Children Hospital from November 2021 to January 2024.They were divided into a control group and an ob-servation group based on different treatment methods.The control group received magnesium sulfate combined with intravenous nutritional support therapy,while the observation group received low-molecular-weight heparin combined with magnesium sulfate and intravenous nutritional support therapy.Both groups were treated for 5 days.The fetal growth and development indicators,umbilical artery hemodynamic indicators,and perinatal indicators were compared between the two groups,and the safety of medication was evaluated.Results After treatment,the biparietal diameter,head circumference,abdominal circumference,and femur length in the observation group were significantly higher than those in the control group (t=6.655,7.466,2.485,24.565,all P<0.05);and the systolic to diastolic velocity ratio (S/D value),resistance index (RI),and pulsatility index (PI) in the observation group were significantly lower (t=5.790,5.058,5.639,all P<0.05).The gestational age at delivery,neonatal weight,and pla-cental weight in the observation group were significantly higher (t=7.542,16.692,16.043,all P<0.05).There were no significant differences in 1-min and 5-min Apgar scores between the two groups (t=1.150,0.530,P>0.05).No complications such as allergic reactions,thrombocytopenia,or coagulation disorders occurred during treatment.Conclusion The treatment of FGR with low-molecular-weight heparin combined with magnesium sulfate and in-travenous nutrition can effectively promote fetal growth and development,improve fetal umbilical artery hemody-namics,and improve fetal outcomes.
Fetal growth retardationMagnesium sulfatePregnant women
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