Therapeutic effect of Bifidobacterium triple active bacteria capsule combined with Silymarin on non-alcoholic steatohepatitis patients and its impact on gut microbiota
Objective To explore the efficacy of bifidobacterium triple viable capsules combined with silybin in the treatment of non-alcoholic steatohepatitis patients and its impact on gut microbiota.Methods A total of 138 patients with non-alcoholic steatohepatitis admitted to our hospital's infection department were selected and divided into three groups:Silymarin group (treated with Silymarin),Bifidobacterium triple active bacteria capsule group (treated with Bifidobacterium triple active bacteria capsule),and combination group (treated with Bifidobacterium triple active bacteria capsule group),with 46 cases in each group.The clinical efficacy,fecal microbiota,liver function,serum endotoxin and other indicators of the three groups were compared.Results The clinical total effective rate of the combination group (95.6％) was significantly better than that of the Silymarin group (78.3％) and the Bifidobacterium triple active capsule group (82.6％) (X2=5.842,4.127,all P<0.05);there was no significant difference in the total effective rate between the Silymarin group and the Bifidobacterium triple active capsule group (X2=0.963,P>0.05);After treatment,the number of Bifidobacterium and Lactobacillus in the combination group was higher than that of the Silymarin group and the Bifidobacterium triple active capsule group (t=4.731,3.710,4.124,3.752,all P<0.05),while the number of Staphylococcus and Escherichia coli was significantly lower than that of the Silymarin group and the Bifidobacterium triple active capsule group ( t=3.152,3.853,4.117,3.924,all P<0.05);Serum ALT,AST The levels of endotoxins and BMI were significantly lower in the Silymarin group and Bifidobacterium triple active capsules group (t=4.942,5.113,3.758,3.165,4.073,3.250,4.114,3.541,all P<0.05).Conclusion The combination of bifidobacterium triple viable capsules and silybin treatment can effectively regulate the imbalance of intestinal microbiota in patients with non-alcoholic steatohepatitis,improve liver function,reduce serum endotoxin levels,and have significant therapeutic effects.
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