Effects of modified Kushen decoction combined with western medicine on clinical efficacy,and peripheral blood inflammatory factors in patients with chronic eczema
Objective To study the clinical effect and influence of modified Kushen decoction combined with western medicine in the treatment of patients with chronic eczema of spleen deficiency and dampness accu-mulation type. Methods A total of 192 patients with chronic eczema of spleen deficiency and dampness accumu-lation type in Wenzhou Traditional Chinese Medicine Hospital were selected from February 2022 to January 2024 and performed retrospective analysis. According to different treatment methods,all the patients were divided into a western medicine group (n=89) and a combination group (n=103). Patients in the western medicine group received western medicine treatment,while patients in the combination group received conventional western medicine com-bined with modified Kushen decoction treatment. The course of treatment in both groups was 4 weeks. The clinical efficacy,skin lesion degree[eczema area and severity index (EASI) scores],pruritus degree[visual analogue scale (VAS) score],peripheral blood inflammatory factors and adverse conditions were compared between the two groups. Results The total effective rate of clinical treatment in combined group was 97.1％,which was higher than 88.8％ in western group (P<0.05). After treatment,the EASI scores of lesion area,papule,exfoliation and lich-enization in combined group were lower than those in western medicine group (P<0.05). After 2 and 4 weeks of treatment,VAS scores in combined group were lower compared to western medicine group (P<0.05). After treat-ment,the levels of γ-interferon,interleukin-4 and C-reactive protein (CRP) in combined group were lower than those in western medicine group (P<0.05). There was no statistical difference in the total incidence rate of adverse drug reactions between the combined group (6.8％) and the western group (3.4％) (P>0.05). Conclusion Modified Kushen decoction combined with western medicine has a significant clinical effect in the treatment of patients with chronic eczema of spleen deficiency and dampness accumulation type. It can effectively alleviate the skin lesions and pruritus symptoms,and improve the inflammatory indicators,and it has good safety.
Modified kushen decoctionSpleen deficiency and dampness accumulation typeEczemaTreatment outcomeInfluence
万方数据
维普
