Observation of the clinical efficacy of Xuefuzhuyu Decoction and Wuling Powder in the treatment of diastolic heart failure in the elderly patients(Qi deficiency and water stasis pattern)
Objective To investigate the clinical efficacy of Xuefuzhuyu Decoction and Wuling Powder in the treatment of diastolic heart failure (DHF) in the elderly patients. Methods A total of 114 DHF patients admitted to Wenzhou Traditional Chinese Medicine Hospital were screened,including the control group (n=57) and the combi-nation group (n=57). The control group was given conventional western medicine,and the combined group was given Xuefuzhuyu Decoction and Wuling Powder on the basis of the control group,and the both groups were treated continuously for 4 weeks. The clinical effect after treatment was evaluated. And the TCM syndrome score,echocardiogram index,biochemical index and walking test before and after treatment were compared to cal-culate the occurrence of adverse reactions during treatment. Results After 2 weeks of treatment,the main dis-ease,secondary disease and total score of the combined group were lower than those of the control group (t major disease=2.782,P=0.006;t secondary disease=2.909,P=0.004;t total score=3.129,P=0.002);and all scores after 4 weeks of treatment were lower than after treatment 2,the difference was statistically significant (t major disease=4.977,P<0.001;t secondary disease=12.304,P<0.001;t total score=8.040,P<0.001). The total effective rate of the combined group was higher than that of the control group (89.5％vs 73.7％,x2=4.728,P<0.05). After treatment,the ratio of left atrial volume index (LAVI),left ventricular mass index (LVMI) and mitral flow spectrum peak velocity to mitral ring peak velocity at early di-astolic stage (E/E') in combination group was lower than that in control group (t=5.163,P<0.001;t=3.408,P=0.001;t=6.163,P<0.001). The ratio of mitral peak blood flow (E/A) in early and late diastolic periods was higher than that in control group (t=6.023,P<0.001). After treatment,the level of plasma NT-proBNP in combination group was lower than that in control group (t=16.411,P<0.001),and the distance of 6 min walking test (6MWT) in combination group was higher than that in control group (t=6.975,P<0.001). There was no significant difference in the incidence of adverse reactions between the combined group and the control group (12.3％ vs 8.8％,x2=0.373,P>0.05). Conclusion Xuefuzhuyu Decoction combined with Wuling Powder can significantly improve the cura-tive effect,improve clinical symptoms and cardiac function,and effectively reverse cardiac remodeling in the treatment of Syndrome of Qi deficiency and water stopping blocking blood stasis DHF with good safety.
Heart failure,diastolicSyndrome of Qi deficiency and water stopping blocking blood stasisXue Fu Zhu Yu TangWu Ling San
万方数据
维普
