Curative effect of continuous pumping of pralidoxime iodide combined with hemoperfusion and its influences on changes of ChE activity,CRP,WBC and NEUT in acute organophosphorus pesticide poisoning
Objective To explore the curative effect of continuous pumping of pralidoxime iodide combined with hemoperfusion and its influences on changes of cholinesterase (ChE) activity,C-reactive protein (CRP),white blood cell count (WBC) and neutrophil (NEUT) in acute organophosphorus pesticide poisoning (AOPP). Methods According to retrospective and convenient sampling method,a total of 80 patients with AOPP admitted to Xinchang County People's Hospital,were enrolled as the research objects between June 2022 and June 2024. According to different treatment methods,they were divided into a control group (continuous pumping of pralidoxime iodide till ChE recovery,38 cases) and a study group[continuous pumping of pralidoxime iodide combined with hemoperfusion (the first hemoperfusion within 24 h after poisoning and the second hemoperfusion within 24～48 h after poisoning),42 cases]. After treatment,clinical curative effect in the two groups was compared. The recovery indexes were recorded. The changes of ChE activity,levels of WBC,NEUT and CRP were compared before and after treatment,and occurrence of complications was recorded. Results After treatment,total response rate in study group was higher than that in control group[92.9％(39/42) vs 76.3％(29/38),P<0.05]. The dosage of pralidoxime iodide in study group was fewer than that in control group,interval from coma to awaking and length of hospital stay were shorter than those in control group (P<0.05). At 24 h,72 h and 7 d after treatment,ChE levels were increased in both groups,which were higher in study group than control group (P<0.05). After treatment,WBC,NEUT and CRP were decreased in both groups,which were lower in study group than control group (P<0.05). There was no significant difference in total incidence of complications between study group and control group[4.8％ (2/42) vs 10.5％ (4/38),P>0.05]. Conclusion Curative effect of continuous pumping of pralidoxime iodide combined with hemoperfusion is good in AOPP,which can increase ChE level and reduce inflammatory response.
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