Clinical efficacy of cyclosporine in the treatment of patients with unexplained recurrent implantation failure
Objective To investigate the clinical efficacy and offspring risk of Cyclosporin A (CsA) in the treatment of patients with unexplained repeated recurrent implantation failure (RIF). Methods A total of 220 pa-tients with unexplained RIF who received treatment in Wenzhou Medical University Affiliated Xinchang Hospital from June 2021 to October 2022 were selected and divided into a control group (n=110,conventional treatment) and an observation group (n=110,conventional treatment+CsA) according to different treatment methods. The clinical pregnancy rate,embryo implantation rate,miscarriage rate,immune indicators,incidence of pregnancy complications,and adverse reactions were compared between the two groups. Results The clinical pregnancy rate (48.2％vs 25.5％) and embryo implantation rate (51.8％ vs 30.9％) of the observation group were significantly high-er than those of the control group,but the miscarriage rate of the observation group was significantly lower than that of the control group (5.4％ vs 17.3％) (P<0.05). There was no significant difference in various immune indica-tors between the two groups before treatment (P>0.05). After treatment,the levels of interferon-γ(IFN-γ) and tumor necrosis factor-α (TNF-α) in both groups were significantly lower than those in the control group,but the levels of interleukin-10 (IL-10) were significantly higher than those in the control group (P<0.05);The total incidence of pregnancy complications (5.4％ vs 20.0％) and adverse reactions (5.4％ vs 18.2％) in the observation group were significantly lower than those in the control group (P<0.05). Conclusion The treatment of patients with unex-plained RIF by CsA can effectively improve the live birth rate,clinical pregnancy rate,and embryo implantation rate,reduce the miscarriage rate,pregnancy complications,and adverse reactions of the patients,strengthen the im-mune function of the patients,and have a low risk of the offspring,which is worth adopting in the clinic.
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