Study on the Efficacy and Safety of Roxadustat in the Treatment of Patients with Chronic Kidney Disease Complicated with Renal Anemia
Objective:To investigate the clinical effect and safety of Roxadustat in the treatment of patients with chronic kidney disease complicated with renal anemia.Method:A total of 96 patients with chronic kidney disease complicated with renal anemia admitted to Changzhou No.7 People's Hospital from January 2021 to June 2022 were selected and divided into two groups according to computer random number method,with 48 cases in each group.The control group was given routine clinical treatment,and the study group was given Roxadustat treatment on the basis of the control group.The efficacy,levels of inflammatory factors,anemia-related indexes and drug safety were compared between the two groups.Result:The total effective rate of the study group was significantly higher than that of the control group(P＜0.05).Before treatment,there were no significant differences in the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C reactive protein(hs-CRP)and procalcitonin(PCT)between the two groups(P＞0.05).After treatment,the levels of TNF-α,IL-6,hs-CRP and PCT in both groups were lower than those before treatment,and those in the study group were significantly lower than those in the control group(P＜0.05).Before treatment,there were no significant differences in the levels of hemoglobin(Hb),red blood cell count(RBC),serum ferritin(SF)and hepcidin(Hepc)levels between the two groups(P＞0.05).After treatment,the levels of Hb,RBC and SF in both groups were significantly higher than those before treatment,and those in the study group were significantly higher than those in the control group(P＜0.05).The levels of Hepc in the two groups after treatment were significantly lower than those before treatment,and that in the study group was significantly lower than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Roxadustat is used in the clinical treatment of patients with chronic kidney disease complicated with renal anemia,the inflammation and anemia situation of patients have been significantly improved,and the clinical efficacy has been significantly improved,and the drug is relatively safe and controllable.
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NSTL
万方数据
维普
