Effects of Dexmedetomidine Nasal Administration Assisted General Anesthesia on Hemodynamics and Stress Indexes in Patients Undergoing Nasal Endoscopic Surgery
Objective:To investigate the effects of Dexmedetomidine(Dex)nasal administration assisted general anesthesia on hemodynamics and stress indexes in patients undergoing endoscopic nasal surgery.Method:A total of 80 patients with nasal endoscopic surgery admitted to the General Hospital of Pingxiang Mining Group Co.,LTD.from March 2020 to August 2022 were selected and divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was given normal saline nasal administration assisted general anesthesia,and the observation group was given Dex nasal administration assisted general anesthesia.The hemodynamics[heart rate(HR),mean arterial pressure(MAP)]were compared between the two groups before administration(T0),30 min after administration(T1),the end of operation(T2)and the time of extubation(T3).Before and after operation,stress response[serum cortisol(Cor),norepinephrine(NE)]was compared between the two groups.Result:The results of overall analysis showed that there were statistically significant differences in the MAP and HR time,inter-group and interaction(P<0.05).Further pairwise comparison within the group showed that there were no statistically significant differences in hemodynamic indexes at T0 between the two groups(P>0.05).At T1,T2 and T3,MAP and HR of the control group were higher than those at T0,those of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05);there were no statistically significant differences in MAP and HR between T1,T2,T3 and T0 in the observation group(P>0.05).After extubation,the serum Cor and NE levels of the two groups were significantly increased,but those in the observation group were lower than those in the control group,with statistical differences(P<0.05).Conclusion:Dex nasal administration assisted general anesthesia can maintain hemodynamic stability and reduce the stress response of patients undergoing nasal endoscopic surgery,which has certain application value.
Nasal endoscopic surgeryGeneral anesthesiaDexmedetomidineNasal administrationHemodynamicsStress index