Clinical Effect Observation of Transcatheter Aortic Valve Replacement in the Treatment of Severe Aortic Stenosis
Objective:To investigate the clinical effect of transcatheter aortic valve replacement in the treatment of severe aortic stenosis.Method:A total of 75 patients with severe aortic stenosis admitted to Nanchang First Hospital from February 2019 to September 2022 were selected,all of whom received transcatheter aortic valve replacement.Cardiac function indexes,C1q/TNF-related protein-3(CTRP-3),Nod-like receptor thermal protein domain associated protein 3(NLRP3),interleukin-18(IL-18),interleukin-1β(IL-1β)and the incidence of primary/secondary endpoint event were compared before and after surgery.Result:1 month after surgery,the aortic valve mean pressure gradient and aortic peak velocity were lower than those before surgery,and the aortic valve orifice area and left ventricular ejection fraction were higher than those before surgery,the differences were statistically significant(P＜0.05).There were no significant differences in left ventricular mass index and left ventricular end-diastolic diameter between patients before and 1 month after surgery(P＞0.05).1 month after surgery,CRTP-3,NLRP3,IL-1β and IL-18 were lower than those before surgery,the differences were statistically significant(P＜0.05).Of the 75 patients,8 patietns(10.67%)had primary/secondary endpoint event.Conclusion:Transcatheter aortic valve replacement in the treatment of severe aortic stenosis is beneficial to the recovery of cardiac function and the reduction of inflammatory reaction.The incidence of primary/secondary endpoint event is acceptable,and the prognosis of patients is good.
Severe aortic stenosisTranscatheter aortic valve replacementCardiac functionEndpoint event
国家科技期刊平台
NSTL
万方数据
维普
