Evaluation of the Efficacy of Two Preoperative Neoadjuvant Chemotherapy Methods for Advanced Cervical Cancer
Objective:To compare the therapeutic effect and prognostic evaluation of preoperative selective bilateral iliac artery infusion chemotherapy and embolization with systemic intravenous chemotherapy in patients with advanced cervical cancer.Method:A total of 65 patients with advanced cervical cancer admitted to the Gynecology Department of the 960th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from October 2018 to December 2020 were selected as the research objectives,according to different preoperative neoadjuvant chemotherapy(NACT)methods,33 cases were divided into group A(preoperative selective bilateral iliac artery infusion chemotherapy with embolization and cervical cancer radical surgery)and 32 cases in group B(systemic intravenous chemotherapy and cervical cancer radical surgery),the two groups were contrasted with each other.The total effective rate,tumor size change,serum squamous cell carcinoma antigen(SCCA)level and postoperative follow-up of malignant tumor recurrence were compared between the two groups.Result:There was no significant difference in total response rate between the two groups after chemotherapy(P>0.05).There were no significant differences in maximum tumor diameter and SCCA between the two groups before chemotherapy(P>0.05);after chemotherapy,the maximum tumor diameter and SCCA in group A were better than those in group B,the differences were statistically significant(P<0.05);1 week after surgery,SCCA in group B was lower than that in group A,the difference was statistically significant(P<0.05).There was no significant difference in recurrence rate between the two groups(P>0.05).Conclusion:Both preoperative selective bilateral iliac artery infusion chemotherapy and embolization therapy and systemic venous chemotherapy have shown good therapeutic effects on cervical malignant tumors.However,selective bilateral iliac artery infusion chemotherapy and embolization therapy are slightly better than systemic venous chemotherapy,no statistically significant difference,the former has a more significant effect on reducing tumor tissue volume,can more effectively reduce SCCA,and has a lower postoperative recurrence rate than the latter.
Advanced cervical cancerArterial interventional chemotherapy and embolizationSystemic intravenous chemotherapyRadical resection of cervical cancer
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维普
