首页|血必净联合控制性阶梯式减压术对重型颅脑损伤疗效及脑血流动力学的影响

血必净联合控制性阶梯式减压术对重型颅脑损伤疗效及脑血流动力学的影响

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目的:探讨血必净联合控制性阶梯式减压术对重型颅脑损伤患者疗效及脑血流动力学的影响.方法:选取 2019 年 7 月—2022 年 10 月新泰市人民医院收治的 68 例重型颅脑损伤患者,以随机数字表法分成研究组(n=34)与对照组(n=34).对照组给予控制性阶梯式减压术治疗,研究组给予血必净联合控制性阶梯式减压术治疗.比较两组临床疗效、脑血流动力学、神经功能、预后及并发症发生率.结果:研究组治疗总有效率(97.06%)较对照组(76.47%)更高(P<0.05).术后 7 d,两组脑血容量(CBV)、脑血流量(CBF)较术前均增加(P<0.05),达峰时间(TTP)、平均通过时间(MTT)均缩短(P<0.05);与对照组相比,研究组CBV、CBF均更高(P<0.05),TTP、MTT均更短(P<0.05).术后 7 d,两组格拉斯哥预后(GOS)评分较术前均提高(P<0.05),神经功能缺损程度评分量表(CSS)评分较术前均降低(P<0.05);与对照组相比,研究组GOS评分更高(P<0.05),CSS评分更低(P<0.05).研究组并发症发生率(5.88%)较对照组(26.47%)更低(P<0.05).结论:血必净联合控制性阶梯式减压术用于治疗重型颅脑损伤,可促进临床疗效提高,增强脑血流动力学,改善患者神经功能及预后,降低并发症发生风险.
Effects of Xuebijing Combined with Controlled Stepwise Decompression on Severe Craniocerebral Injury and Its Influence on Cerebral Hemodynamics
Objective:To explore the effect of Xuebijing combined with controlled stepwise decompression in patients with severe craniocerebral injury and its influence on cerebral hemodynamics.Method:A total of 68 patients with severe craniocerebral injury who were admitted in Xintai People's Hospital from July 2019 to October 2022 were selected,and divided into the study group(n=34)and the control group(n=34)by random number table method.The control group was treated with controlled stepwise decompression,and the study group was treated with Xuebijing combined with controlled stepwise decompression.The clinical efficacy,cerebral hemodynamics,neurological function,prognosis and incidence of complications of the two groups were compared.Result:The total effective rate of treatment in the study group(97.06%)was higher than that in the control group(76.47%)(P<0.05).7 days after surgery,cerebral blood volume(CBV)and cerebral blood flow(CBF)in both groups were increased compared to those preoperative(P<0.05),time to peak(TTP)and mean transite time(MTT)were shortened(P<0.05);in comparision of the control group,CBV and CBF in the study group were higher(P<0.05),TTP and MTT were shorter(P<0.05).7 days after surgery,Glasgow outcome scale(GOS)scores in both groups were increased compared to those preoperative(P<0.05),and China stroke scale(CSS)scores were decreased(P<0.05);in comparision of the control group,the GOS score in the study group was higher(P<0.05),and the CSS score was lower(P<0.05).The incidence of complications in the study group(5.88%)was lower than that in the control group(26.47%)(P<0.05).Conclusion:Xuebijing combined with controlled stepwise decompression in the treatment of severe craniocerebral injury,can promote clinical efficacy,enhance cerebral hemodynamics,improve patient neurological function and prognosis,and reduce the risk of complications.

Severe craniocerebral injuryXuebijingControlled stepwise decompressionCerebral hemodynamics

尹成国、董三军

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新泰市人民医院神经外科 山东 新泰 271200

山东健康集团新汶中心医院影像科 山东 泰安 271219

重型颅脑损伤 血必净 控制性阶梯式减压术 脑血流动力学

2024

中国医学创新
中国保健协会

中国医学创新

影响因子:1.706
ISSN:1674-4985
年,卷(期):2024.21(2)
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