Effects of Bronchoscopy Alveolar Lavage Combined with Local Administration of Amikacin on Inflammatory Factors and Clinical Symptoms in Patients with Bronchiectasis and Infection
Objective:To analyze the therapeutic effect of bronchoscopy alveolar lavage combined with local administration of Amikacin in patients with bronchiectasis and infection.Method:A total of 80 patients with bronchiectasis and infection admitted to Fengcheng Mining Bureau General Hospital from July 2021 to January 2023 were selected,and divided into two groups by random number table method,with 40 cases in each group.The control group was treated with routine treatment + bronchoscopy alveolar lavage,and the observation group was treated with local administration of Amikacin,continuous treatment for 2 weeks.The clinical efficacy,symptom improvement,inflammatory factor levels,and lung function between the two groups were compared.Result:The total effective rate for treatment of the observation group was 95.00%(38/40),which was higher than 80.00%(32/40)of the control group(P<0.05).The disappearance time of cough was(4.26±0.89)d,the disappearance time of fever was(3.19±0.63)d,and the disappearance time of lung moist rales was(7.21±1.34)d in the observation group,which were shorter than(6.31±1.59),(5.48±1.20),(9.75±1.88)d in the control group,the differences were statistically significant(P<0.05).Before treatment,there were not statistical differences between the two groups in terms of procalcitonin(PCT),C reactive protein(CRP),forced expiratory volume in the first second(FEV1),peak expiratory flow(PEF),and forced vital capacity(FVC)(P>0.05);after treatment,the PCT and CRP of the observation group were(0.84±0.15)ng/mL and(6.20±1.28)mg/L,which were lower than(1.38±0.26)ng/mL,(8.31±1.57)mg/L of the control group,FEV1 was(2.25±0.58)L,PEF was(3.48±0.69)L/s,and FVC was(3.41±0.71)L in the observation group,which were higher than(1.78±0.43)L,(2.69±0.58)L/s,(2.96±0.60)L of the control group,the differences were statistically significant(P<0.05).Conclusion:Bronchoscopy alveolar lavage + local administration of Amikacin can accelerate the regression of symptoms in patients with bronchiectasis and infection,reduce the level of inflammatory factors,and improve lung function.
InfectionProcalcitoninBronchiectasiaPeak expiratory flowC reactive protein
万方数据
维普
