Effects of Low-dose Aspirin Combined with Letrozole on Ovarian Blood Flow and Serum Sex Hormones in Patients with Polycystic Ovary Syndrome
Objective:To investigate the clinical effect of low dose Aspirin combined with Letrozole in patients with polycystic ovary syndrome.Method:A total of 78 patients with polycystic ovary syndrome who received treatment in the First Affiliated Hospital of Xiamen University from January 2020 to April 2022 were selected and divided into the control group(39 cases)with oral Letrozole and the observation group(39 cases)with oral low-dose Aspirin and Letrozole according to random number table method.All patients were treated for 3 menstrual cycles.The ovarian blood flow,serum sex hormone levels,ovulation and pregnancy status(the patients were followed up at 3 and 6 months after the end of treatment),and adverse reactions between the two groups were compared.Result:After treatment,the observation group exhibited lower pulsatile index(PI)and end diastolic flow velocity(EDV)of the ovaries compared to the control group,while the peak systolic flow velocity(PSV)was higher than that of the control group(P<0.05).Testosterone(T),estradiol(E2),follicle stimulating hormone(FSH),and luteinizing hormone(LH)showed no variation between the two groups before and after treatment(P>0.05).Follow-up conducted for 3 to 6 months revealed a higher ovulation rate and pregnancy rate in the observation group compared to the control group(P<0.05).The rate of adverse reactions between the two groups was no significant difference(P>0.05).Conclusion:The combination therapy of low-dose Aspirin and Letrozole for patients with polycystic ovary syndrome can effectively improve ovarian blood flow,increase ovulation and pregnancy rates,and the combination of the two has high safety,but no significant regulatory effect on sex hormone levels.
Polycystic ovary syndromeAspirinLetrozoleOvarian blood flowSerum sex hormonesOvulation ratePregnancy rate
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维普
