Changes in Serum hs-CRP and sFlt-1 Levels in Patients with Hypertensive Disorders of Pregnancy and Their Correlation with Pregnancy Outcomes
Objective:To investigate the changes of serum soluble fms-like tyrosine kinase receptor 1(sFlt-1)and hypersensitive C reactive protein(hs-CRP)levels and their correlation with pregnancy outcomes in patients with hypertensive disorders of pregnancy(HDP).Method:One hundred and eight HDP patients who received treatment in Ganzhou Maternal and Child Health Hospital from January 2022 to February 2023 were collected as a case group and analyzed retrospectively.According to the severity of the disease,the patients in the case group were divided into gestational hypertension group(43 cases),preeclampsia group(35 cases)and eclampsia group(30 cases),and 82 women with normal pregnancy during the same period were selected as the control group.The changes of serum hs-CRP and sFlt-1 levels in all subjects were analyzed.Result:The serum levels of hs-CRP and sFlt-1 in case group were significantly higher than those in control group(P<0.05).There were significant differences in serum hs-CRP and sFlt-1 levels among gestational hypertension group,preeclampsia group and eclampsia group(P<0.05),and the serum hs-CRP and sFlt-1 levels increased with the severity of the disease(P<0.05).The levels of hs-CRP and sFlt-1 in the adverse pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).The AUC values of serum hs-CRP and sFlt-1 reflecting pregnancy outcome in patients with HDP were 0.758 and 0.763,respectively.Correlation analysis showed that hs-CRP and sFlt-1 were positively correlated(r=0.743,P<0.001).Conclusion:The serum levels of hs-CRP and sFlt-1 in patients with HDP increase and increase with the severity of the disease,and have a certain correlation with pregnancy outcome.
Hypertensive disorders of pregnancyPregnancy outcomeSoluble fms-like tyrosine kinase receptor 1Hypersensitive C reaction protein
万方数据
维普
