Application of Modified Huoluo Zhuyu Formula in Postoperative Patients with Intertrochanteric Fractures
Objective:To explore the application effect of modified Huoluo Zhuyu Formula in postoperative treatment of intertrochanteric fractures(ITF).Method:A total of 64 patients with ITF admitted to Ji'an County Traditional Chinese Medicine Hospital from January 2016 to January 2023 were selected,and were divided into two groups by random number table method,with 32 cases in each group.Both groups were treated with proximal femoral nail antirotation(PFNA)intramedullary nail fixation,while the control group was treated with Low Molecular Weight Heparin Calcium after surgery,the observation group was treated with modified Huoluo Zhuyu Formula for 14 days.The coagulation function,hemorheology indexes,hip joint function,lower limb deep vein thrombosis(DVT)and adverse reactions were compared between the two groups.Result:14 days after surgery,the prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)in the observation group were(12.09±1.18),(30.49±2.28)and(19.82±1.32)s,which were longer than(10.86±1.13),(28.76±2.15)and(17.44±1.22)s in the control group,and the D-dimer(D-D)level was(0.55±0.12)mg/L,which was lower than(0.69±0.14)mg/L in the control group,the differences were statistically significant(P<0.05).At 14 d after surgery,the high shear whole blood viscosity(HBV),low shear whole blood viscosity(LBV),plasma viscosity(PV)and erythrocyte sedimentation rate(ESR)of the observation group were(4.26±0.43),(7.92±1.05),(1.64±0.23)mPa·s and(11.02±1.21)mm/h,respectively,which were lower than(5.19±0.67),(9.34±1.18),(2.02±0.26)mPa·s and(13.38±1.29)mm/h of the control group,the differences were statistically significant(P<0.05).After surgery,joint function,deformity,degree of pain,joint range of motion scores and total score of the Harris hip joint function score in the observation group were(39.82±3.82),(3.09±0.41),(35.09±4.14),(3.94±0.45)and(81.94±5.42)scores,which were all higher than(33.74±3.63),(2.65±0.35),(30.52±3.92),(3.11±0.42)and(70.02±5.39)scores in the control group,the differences were statistically significant(P<0.05).The incidence of lower limb DVT in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There was not statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application of modified Huoluo Zhuyu Formula combined with Low Molecular Weight Heparin Calcium after ITF has significant effect,which can regulate the coagulation function of the body,correct hemorheology indicators,reduce the occurrence of DVT in lower limbs,and is safe and reliable.
Intertrochanteric fractureModified Huoluo Zhuyu FormulaLower limb deep vein thrombosisCoagulation function
万方数据
维普
