The nuclear receptor Nur77 is a product encoded by the immediate early gene NR4A1,which is expressed in various tumor tissues including lung cancer,and is widely involved in the biological process of tumors.Lung cancer is one of the common human malignant tumors with high incidence,complex pathogenesis,difficult to find in the early stage and poor treatment effect.A large number of studies have shown that Nur77 plays an important role in the development,invasion and metastasis,apoptosis,immune regulation and treatment of lung cancer.This article reviews the research progress of Nur77 in lung cancer.
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