Effects of High-frequency rTMS on Improving Sleep and Depressive Disorder in Patients with Alcohol Dependence
Objective:To investigate the effects of high-frequency repetitive transcranial magnetic stimulation(rTMS)on improving sleep and depressive disorder in patients with alcohol dependence.Method:A total of 80 patients with alcohol dependence admitted to the Third People's Hospital of Ganzhou from August 2022 to February 2023 were selected as the study objects,and were divided into two groups according to random number table method,with 40 patients in each group.The control group received pseudo-stimulation therapy,and the observation group received high-frequency rTMS therapy.Both groups were maintained for 4 weeks.Insomnia severity index(ISI),Pittsburgh sleep quality index(PSQI),self-rating depression scale(SDS),self-rating anxiety scale(SAS)scores and neurotransmitter levels were compared between the two groups before treatment and 4 weeks after treatment.Result:Before treatment,there were no significant differences in ISI,each item scores and total scores of PSQI,SDS scores,SAS scores,dopamine(DA)level,5-hydroxytryptamine(5-HT)level between the two groups(P＞0.05).4 weeks after treatment,daytime dysfunction[(1.01±0.11)scores],sleep disorder[(0.84±0.39)scores],initiating sleep time[(0.96±0.17)scores],sleep efficiency[(1.01±0.15)scores],sleep time[(0.71±0.28)scores],sleep quality[(0.87±0.24)scores],hypnotic drug[(0.73±0.22)scores]and total score[(6.13±0.51)scores],ISI[(5.17±2.12)scores],SDS[(39.27±7.15)scores],SAS[(32.15±6.33)scores],DA[(71.32±4.35)ng/L]in the observation group were lower than those in the control group[(1.53±0.21)scores,(1.34±0.60)scores,(1.65±0.36)scores,(1.44±0.32)scores,(1.30±0.35)scores,(1.53±0.31)scores,1.30±0.34)scores,(10.09±0.82)scores,(8.36±4.09)scores,(47.22±8.56)scores,(43.05±7.96)scores,(87.88±5.62)ng/L],and the 5-HT[(269.72±27.04)ng/mL]in observation group was higher than that in control group[(197.33±25.88)ng/mL],the differences were statistically significant(P＜0.05).Conclusion:High-frequency rTMS therapy can significantly improve the sleep quality of patients with alcohol dependence,effectively relieve patients'negative emotion,and further enhance patients'neurological function.
万方数据
维普
