Analysis of Dynamic Expression of Serum Chemokine CXCL12,RANTES,MIP-1α and Its Correlation with the Degree of Neurological Function Defect and Prognosis in Patients with Acute Cerebral Infarction
Objective:To investigate the dynamic expression of serum chemokine CXC motif chemokine ligand 12(CXCL12),regulated upon activation normal T cell expressed and secreted(RANTES),macrophage inflammatory protein-1α(MIP-1α)and its correlation with the degree of neurological function defect and prognosis in patients with acute cerebral infarction.Method:A total of 80 ACI patients admitted to the Third People's Hospital of Ganzhou from July 2021 to July 2022 were selected as ACI group,and another 80 volunteers with normal neurological function during the same period were selected as control group.The levels of CXCL12,RANTES and MIP-1α were compared between ACI group and control group,different degree of neurological function defect and prognosis situation.The correlation between the above serum indexes and the degree of neurological function defect were analyzed.Receiver operator characteristic(ROC)curve was drawn to analyze the predictive value of various serum indexes for poor prognosis of ACI patients.Result:The levels of CXCL12,RANTES and MIP-1α in ACI group were higher than those in control group(P＜0.05).The levels of CXCL12,RANTES and MIP-1α in severe defect group were higher than those in mild and moderate defect group,and those in moderate defect group were higher than those in mild defect group(P＜0.05).The levels of CXCL12,RANTES and MIP-1α in poor prognosis group were higher than those in good prognosis group(P＜0.05).Kendall's tau-b correlation analysis showed that the levels of serum CXCL12,RANTES and MIP-1α were positively correlated with the degree of neurological function defect in ACI patients(τ=0.566,0.678,0.752,P＜0.001).ROC curve showed that the area under the curve(AUC)of serum CXCL12,RANTES and MIP-1α levels single and combined detection were all greater than 0.8 in predicting the poor prognosis of ACI patients,and the combined detection had a higher value.Conclusion:Serum CXCL12,RANTES and MIP-1α levels in ACI patients are all highly expressed,and the higher the level,the more serious the neurological function defect and the higher the risk of poor prognosis.
Acute cerebral infarctionCXC motif chemokine ligand 12Regulated upon activation normal T cell expressed and secretedMacrophage inflammatory protein-1αNeurological function defectPrognosis
万方数据
维普
