The Predictive Value of Combined Detection of Anti Nuclear Antibodies and T Lymphocyte Subsets for Recurrent Miscarriage Pregnancy Outcomes
Objective:To explore the predictive value of anti nuclear antibody(ANA)combined with T lymphocyte subpopulations detection in pregnancy outcomes of recurrent spontaneous abortion(RSA).Method:A total of 50 RSA patients admitted to Ganzhou Maternal and Child Health Hospital from February 2020 to July 2022 were selected as the study group,and another 50 normal pregnant women who underwent prenatal examinations in author's hospital during the same period were selected as the control group.5 mL fasting elbow venous blood was collected from all subjects in the morning to detect the levels of ANA and T lymphocyte subpopulations(CD4+,CD8+,CD16+CD56+),and the CD4+/CD8+ ratio was calculated.Result:A total of 29 patients in the study group experienced miscarriage before 10 weeks of pregnancy,with a miscarriage rate of 58.00%(29/50);there were 13 cases of miscarriage in the control group before 10 weeks of pregnancy,with a miscarriage rate of 26.00%(13/50).The difference in miscarriage rates between the two groups was statistically significant(x2=10.509,P=0.001).Compared with the control group,the positive detection rate of ANA in the study group was higher,with higher levels of CD4+,CD16+CD56+,CD4+/CD8+,and lower levels of CD8+,the differences were statistically significant(P＜0.05).Joint detection had the highest predictive value in RSA,with an AUC of 0.872,sensitivity of 0.875,specificity of 0.393,followed by CD16+CD56+,CD4+,CD4+/CD8+,CD8+,ANA.Conclusion:The application value of ANA combined with T lymphocyte subpopulations has high application value in the diagnosis of RSA,which can effectively predict the risk of RSA occurrence and provide reliable reference for early clinical intervention.
万方数据
维普
