The Relationship between MRI Findings,p53 Expression,and Clinical Pathology of Ductal Carcinoma in Situ of the Breast
Objective:To explore and analyze the relationship between magnetic resonance imaging(MRI)findings,p53 protein(p53)expression and clinicopathology in ductal carcinoma in situ of breast(DCIS).Method:A retrospective study was conducted on MRI plain scan + enhancement data of 60 patients with surgically and pathologically confirmed DCIS in Nanchang People's Hospital between January 2018 and December 2021,the pathological grading and MRI findings[dynamic enhancement curve,early enhancement rate,apparent diffusion coefficient(ADC),focal morphology]of patients were observed and recorded,the expression of p53 in carcinoma tissues was detected by immunohistochemistry,the relationship between MRI findings,p53 expression and clinicopathology was analyzed.Result:The main MRI findings in DCIS patients were non-mass enhancement[37 cases(61.67%,37/60)],which was mainly on segmental enhancement(19 cases,51.35%)and cluster-ring enhancement(17 cases,45.95%).The dynamic enhancement curves were mainly on type Ⅰ(25 cases,41.67%),and early enhancement rate was mainly on fast enhancement(22 cases,36.67%).The proportion of cases with ADC value＜1.0×10-3 mm2/s was high[65.00%(39/60)].The proportions of type Ⅲ TIC and early fast enhancement in p53 positive and high nuclear grading were significantly higher than those in p53 negative and non-high nuclear grading,the differences were statistically significant(P＜0.05);but there were not significant differences in morphology,distribution of non-mass enhancement,internal enhancement or ADC among patients with different p53 expression(positive,negative)and pathological grading(high nuclear grade,non-high nuclear grade)(P＞0.05).The expression of p53 was related to pathological grading.The incidence of p53 positive was higher in patients with high nuclear grade of DCIS,the difference was statistically significantly(P＜0.05).Conclusion:MRI findings are specific in DCIS patients,which are mainly characterized by non-mass enhancement with segmental distribution and cluster-ring enhancement,and early fast enhancement and type Ⅰ TIC curves are common.MRI findings are related to p53 expression and pathological grade.The analysis of MRI findings can provide reference for the treatment and prognosis of DCIS patients.
Ductal carcinoma in situ of breastMagnetic resonance imagingp53 proteinPathological grading
万方数据
维普
