中国医学创新2024,Vol.21Issue(4) :156-162.DOI:10.3969/j.issn.1674-4985.2024.04.036

肠道菌群在老年慢性阻塞性肺疾病合并肌少症中的机制探讨

Study on the Mechanism of Intestinal Microflora in Elderly Patients with Chronic Obstructive Pulmonary Disease Complicated with Sarcopenia

马娇娇 夏晓黎 王亚锋 马艳萍 刘文慧
中国医学创新2024,Vol.21Issue(4) :156-162.DOI:10.3969/j.issn.1674-4985.2024.04.036

肠道菌群在老年慢性阻塞性肺疾病合并肌少症中的机制探讨

Study on the Mechanism of Intestinal Microflora in Elderly Patients with Chronic Obstructive Pulmonary Disease Complicated with Sarcopenia

马娇娇 1夏晓黎 2王亚锋 2马艳萍 2刘文慧1
扫码查看

作者信息

  • 1. 甘肃中医药大学中西医结合学院 甘肃 兰州 730000
  • 2. 甘肃中医药大学附属医院老年病科 甘肃 兰州 730000
  • 折叠

摘要

肌少症在老年慢性阻塞性肺疾病人群中患病率较高,与慢性阻塞性肺疾病密切相关.两者共存不仅损害患者身心健康,还增加了临床治疗的难度.现代医学对慢性阻塞性肺疾病合并肌少症的发病机制研究较少,临床治疗也以对症处理为主,以缓解症状、减少COPD急性发作次数为目的.对于老年慢性阻塞性肺疾病和肌少症临床共病之间可能存在内在联系,但目前对该合并症关注不足.随着生物技术的不断进步,肠道菌群的作用在许多慢性疾病的发病机制中越来越受到重视.有研究表明,老年慢性阻塞性肺疾病患者肠道菌群存在明显失衡,而肌少症的发生也与肠道菌群关系较为密切.本文通过探讨肠道菌群与老年慢性阻塞性肺疾病合并肌少症之间的相互关系,分析肠道菌群的失衡可能是导致老年慢性阻塞性肺疾病合并肌少症的关键因素之一,提出以微生态疗法调节肠道菌群失衡,可能成为临床防治老年慢性阻塞性肺疾病合并肌少症的一种新途径.

Abstract

Sarcopenia is high in the prevalence of chronic obstructive pulmonary disease in the elderly,which is closely related to chronic obstructive pulmonary disease.The coexistence of the two not only harms the physical and mental health of patients,but also increases the difficulty of clinical treatment.Modern medicine has less pathogenic mechanisms for chronic obstructive pulmonary diseases and sarcopenia.Clinical treatment is mainly based on symptomatic treatment,with the purpose of alleviating symptoms and reducing COPD acute seizures.There may be an intrinsic relationship between chronic obstructive pulmonary disease and sarcopenia in the elderly,but insufficient attention has been paid to this comorbidity.With the continuous advancement of biotechnology,the role of intestinal flora has become increasingly valued in the pathogenesis of many chronic diseases.Studies have shown that the intestinal flora in patients with chronic obstructive pulmonary diseases has obvious imbalances,and the occurrence of sarcopenia is also closely related to the intestinal flora.By exploring the interaction between the intestinal flora and the chronic obstructive pulmonary disease of the elderly,the analysis of the imbalance of the intestinal flora may be one of the key factors that cause chronic obstructive pulmonary disease in the elderly.It is proposed to regulate the imbalance of intestinal flora with micro-ecological therapy,which may become a new way to clinical prevention and treatment of chronic obstructive pulmonary disease and sarcopenia.

关键词

老年/慢性阻塞性肺疾病/肌少症/肠道菌群

Key words

Elderly/Chronic obstructive pulmonary disease/Sarcopenia/Intestinal flora

引用本文复制引用

基金项目

甘肃省中医药科研课题(G21cp-2022-19)

兰州市科技局发展计划项目(2022-ZD-86)

出版年

2024
中国医学创新
中国保健协会

中国医学创新

影响因子:1.706
ISSN:1674-4985
参考文献量70
段落导航相关论文