首页|经鼻高流量氧疗与无创机械通气治疗慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭的效果

经鼻高流量氧疗与无创机械通气治疗慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭的效果

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
目的:探讨经鼻高流量氧疗(HFNC)与无创机械通气(NIV)治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并Ⅱ型呼吸衰竭的效果.方法:选取 2021 年 5 月—2023 年 5 月河池市第三人民医院急诊医学科收治的 97 例AECOPD合并Ⅱ型呼吸衰竭患者,以随机数字表法分为HFNC组(n=49)和NIV组(n=48).HFNC组给予HFNC治疗,NIV组给予NIV治疗.比较两组住院时间、呼吸支持时间、呼吸困难改善时间、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、动脉血氧饱和度(SaO2)、pH值、舒适状况量表(GCQ)评分、中止治疗率、病死率及并发症发生率.结果:两组住院时间、呼吸支持时间及呼吸困难改善时间比较,差异均无统计学意义(P>0.05).治疗后,两组pH值、SaO2、PaO2比较,差异均无统计学意义(P>0.05),HFNC组PaCO2 高于NIV组(P<0.05).两组 28 d病死率比较,差异无统计学意义(P>0.05);HFNC组GCQ评分高于NIV组,中止治疗率和并发症发生率均低于NIV组(P<0.05).结论:HFNC与NIV治疗AECOPD合并Ⅱ型呼吸衰竭的效果相似,但HFNC舒适度更高、并发症发生及中止治疗风险更低.
Effect of High Flow Nasal Cannula and Non-invasive Ventilation in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Type Ⅱ Respiratory Failure
Objective:To evaluate the effect of high flow nasal cannula(HFNC)and non-invasive ventilation(NIV)in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with type Ⅱ respiratory failure.Method:A total of 97 patients with AECOPD complicated with type Ⅱ respiratory failure admitted to Department of Emergency Medicine,Hechi Third People's Hospital from May 2021 to May 2023 were selected and divided into HFNC group(n=49)and NIV group(n=48)according to random number table method.HFNC group was given HFNC treatment,NIV group was given NIV treatment.The hospital stay,breathing support time,dyspnea improvement time,arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2),pH value,general comfort questionnaire(GCQ)score,treatment discontinuation rate,fatality rate and incidence rate of complications were compared between the two groups.Result:There were no significant differences in hospital stay,breathing support time and dyspnea improvement time between the two groups(P>0.05).After treatment,there were no significant differences in pH value,SaO2 and PaO2 between the two groups(P>0.05),but PaCO2 in HFNC group was higher than that in NIV group(P<0.05).There was no significant difference in 28 d fatality rate between the two groups(P>0.05).The GCQ score in HFNC group was higher than that in NIV group,and the rate of treatment discontinuation and complication were lower than those in NIV group(P<0.05).Conclusion:HFNC and NIV have similar effects in the treatment of AECOPD complicated with type Ⅱ respiratory failure,but HFNC has higher comfort,lower risk of complications and treatment discontinuation.

High flow nasal cannulaNon-invasive ventilationAcute exacerbation of chronic obstructive pulmonary diseaseType Ⅱ respiratory failure

卢三叶、韦尚忠、孙仁权

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河池市第三人民医院急诊医学科 广西 河池 547000

河池市金城江区妇幼保健院麻醉科 广西 河池 547000

经鼻高流量氧疗 无创机械通气 慢性阻塞性肺疾病急性加重期 Ⅱ型呼吸衰竭

2024

10.3969/j.issn.1674-4985.2024.05.006

中国医学创新
中国保健协会

中国医学创新

影响因子：1.706
ISSN：1674-4985
年,卷(期)：2024.21(5)
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