The Effect of Yangxin Shengmai Granules Combined with Nicorandil in the Treatment of Unstable Angina Pectoris and Its Impact on Myocardial Enzyme Spectrum
Objective:To explore the effect of Yangxin Shengmai Granules combined with Nicorandil on unstable angina pectoris and its influence on myocardial energy metabolism.Method:Eighty patients with unstable angina pectoris treated in Wuhan Economic and Technological Development Zone(Hannan District)People's Hospital from October 2020 to October 2022 were selected as the objects of this study.They were divided into control group(n=40)to receive Nicorandil treatment,and observation group(n=40)to receive Nicorandil combined with Yangxin Shengmai Granules treatment by random number table method.Symptom onset[heart rate,daily attack frequency,attack duration],myocardial enzyme profile[lactate dehydrogenase(LDH),creatine kinase isoenzyme(CK-MB),creatine kinase(CK),cardiac troponin I(cTnI)],serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),homocysteine(Hcy),hypersensitive C reactive protein(hs-CRP)],lipid[triglyceride(TG),cholesterol(TC),low density lipoprotein(LDL),high density lipoprotein(HDL)]levels,myocardial energy metabolism,serum free fatty acid levels of the two groups were compared.Result:After treatment,the heart rate and daily frequency of attacks were decreased and the duration of attacks was shortened in both groups,the observation group were superior to the control group,the differences were statistically significant(P<0.05).After treatment,LDH,CK-MB,CK and cTnI were decreased in both groups,and the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of IL-6,TNF-α,Hcy and hs-CRP in both groups were decreased,and the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,HDL-C levels increased and TG,TC and LDL-C decreased in both groups,HDL-C level in observation group was higher than that in control group,TG,TC and LDL-C levels were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,myocardial energy metabolism and serum free fatty acid levels were decreased in both groups,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Yangxin Shengmai Granules combined with Nicorandil in the treatment of patients with unstable angina pectoris has a remarkable effect,which can improve the myocardial ischemia state,reduce the inflammatory response,reduce the level of blood lipids,myocardial energy metabolism and serum free fatty acid level.
Yangxin Shengmai GranulesNicorandilUnstable angina pectorisMyocardial energy metabolismMyocardial enzyme profileInflammatory factors
国家科技期刊平台
NSTL
万方数据
维普
