Effects of Rosuvastatin Combined with Donepezil on Cognitive Function and Activities of Daily Living in Patients with Vascular Dementia
Objective:To investigate the effect of Rosuvastatin combined with Donepezil on cognitive function and activities of daily living in patients with vascular dementia.Method:A total of 98 patients with vascular dementia admitted to Zaozhuang Mental Health Center from May 2020 to November 2022 were selected as the study subjects,and they were divided into two groups by random number table method.The control group(49 cases)received Donepezil,and the observation group(49 cases)received Rosuvastatin and Donepezil.Both groups received the drug for 3 months.The clinical efficacy,cognitive function[mini-mental state examination(MMSE)],inflammatory factors[C reactive protein(CRP)],activities of daily living[activities of daily living scale(ADL)],and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was 89.80%,which was higher than 73.47%of the control group,after treatment,the MMSE and ADL scores of the observation group were higher than those of the control group,while the CRP was lower than that of the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Rosuvastatin combined with Donepezil can improve the cognitive function and the activities of daily living of patients with vascular dementia,regulate the levels of inflammatory factors,has good safety.
Vascular dementiaRosuvastatinDonepezilCognitive functionActivities of daily living
万方数据
维普
