Clinical Effect of Sanqi Tongshu Capsules Combined with Oxiracetam in the Treatment of Vascular Dementia after Cerebral Infarction and Its Influence on Hemorheology Indexes
Objective:To explore the clinical effect of Sanqi Tongshu Capsules combined with Oxiracetam in the treatment of vascular dementia(VD)after cerebral infarction(CI)and its influence on hemorheology indexes.Method:A total of 102 patients with VD after CI who were admitted in Liaoning Jinqiu Hospital from January 2021 to January 2023 were selected and divided into the study group(n=51)and the control group(n=51)by random number table method.The control group was treated with Oxiracetam,and the study group was treated with Sanqi Tongshu Capsules combined with Oxiracetam.All patients were treated for 2 months.The clinical efficacy,dementia degree,hemorheology,cognitive function and ability of daily living of the two groups were compared.Result:The total effective rate of the study group(92.16%)was higher than that(76.47%)of the control group,the difference was statistically significant(P<0.05).After treatment,the clinical dementia rating scale(CDR)scores in both groups were decreased(P<0.05),and the CDR score in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the whole blood low shear viscosity,whole blood high shear viscosity and plasma viscosity in both groups were decreased(P<0.05),and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA)and Barthel index scores in both groups were increased(P<0.05),and those in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Sanqi Tongshu Capsules combined with Oxiracetam in the treatment of VD after CI can improve the clinical efficacy,reduce the degree of dementia,improve hemorheology,and promote cognitive function and daily living ability.
万方数据
维普
