首页|铁死亡在消化道肿瘤中的研究进展

铁死亡在消化道肿瘤中的研究进展

扫码查看
消化道肿瘤是一种常见的恶性肿瘤,对于其治疗和预后的研究一直备受关注.铁死亡作为一种新型的细胞死亡方式,近年来在消化道肿瘤的研究中逐渐受到重视.铁死亡是一种不同于细胞凋亡、细胞焦亡及自噬和非程序性坏死相关的细胞死亡过程的一种细胞死亡方式,其在消化道肿瘤中的作用和机制引起了研究人员的广泛兴趣.铁死亡存在于炎症、缺血再灌注损伤、急性肾损伤及肿瘤中,并在疾病过程中发挥重要作用.铁死亡在消化道肿瘤中的研究具有重要的临床意义,对于深入了解消化道肿瘤的发病机制、开发新的治疗方法具有重要意义.因此,本综述旨在对铁死亡在消化道肿瘤中的研究情况进行总结和分析,以期为相关领域的研究提供理论支持.
Research Progress of Ferroptosis in Gastrointestinal Tumors
Gastrointestinal cancer is a common malignant tumor,and the research on its treatment and prognosis has attracted much attention.As a new type of cell death,ferroptosis has been paid more and more attention in the study of digestive tract tumors in recent years.Ferroptosis is a way of cell death that is different from apoptosis,pyroptosis,autophagy and non-programmed necrosis-related cell death,and its role and mechanism in digestive tract tumors have attracted extensive interest from researchers.Ferroptosis exists in inflammation,ischemia-reperfusion injury,acute kidney injury and tumor,and plays an important role in the process of disease.The study of ferroptosis in digestive tract tumors has important clinical significance,which is of great significance for understanding the pathogenesis of digestive tract tumors and developing new treatment methods.Therefore,this review aims to summarize and analyze the research of ferroptosis in digestive tract tumors,in order to provide theoretical support for the research in related fields.

Gastrointestinal cancerFerroptosisLipid peroxidationResistance

李广昊、王晓通、黄海舸

展开 >

右江民族医学院研究生学院 广西 百色 533000

广西壮族自治区人民医院胃肠疝肠瘘外科 广西 南宁 530021

右江民族医学院附属医院普通外科 广西 百色 533000

消化道肿瘤 铁死亡 脂质过氧化 耐药

国家自然科学基金右江民族医学院附属医院高层次人才项目

82260468R20212602

2024

中国医学创新
中国保健协会

中国医学创新

影响因子:1.706
ISSN:1674-4985
年,卷(期):2024.21(6)
  • 45