Krüppel-like factors(KLF)is a subfamily of zinc finger transcription factor and a group of DNA-binding transcription regulation factors,which have many basic functions in various cells,including proliferation,differentiation,migration,inflammation and angiogenesis.KLF7 is a transcription factor with three highly conserved C2H2 zinc finger motif at the carboxyl terminal.Studies have found that KLF7 has a complex biological role in the occurrence and development of tumors,and plays a role in promoting or suppressing cancer in different types of tumors.This article reviews the research progress of KLF7 in malignant tumors of digestive system.
维普
万方数据