Analysis of the Effect of Different Doses of Tranexamic Acid in the Prevention of Postpartum Hemorrhage in Cesarean Delivery and Its Antifibrinolytic Effect
Objective:To investigate the effect of different doses of Tranexamic Acid in the prevention of postpartum hemorrhage after cesarean delivery and its antifibrinolytic effect.Method:A total of 93 postpartum women who underwent cesarean section at Changtai District Hospital,Zhangzhou City from November 2020 to November 2022 were selected.They were divided into the control group,the low-dose group,and the high-dose group using double-blind random number table method.The control group(n=31)received treatment with Oxytocin,on this basis,the low-dose group(n=31)was treated with 0.5 g Tranexamic Acid combined with 5%Glucose 10 mL after delivery,and the high-dose group(n=31)was treated with 1 g Tranexamic Acid combined with 5%Glucose 10 mL after delivery.The bleeding conditions(amount of bleeding at 2 hours and 24 hours after surgery,bleeding rate),coagulation function[hemoglobin(Hb),hematocrit(HCT),platelet count(PLT),fibrinogen(FIB)],hemorheology[high shear whole blood viscosity,medium shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity],fibrinolysis function[D-dimer(D-D),fibrinolytic degradation products(FDP)],and incidence of adverse reactions were compared.Result:The amount of bleeding in the high-dose group were lower than those in the low-dose group and in the control group at 2 h and 24 h postoperatively(P<0.05);the postpartum hemorrhage rate in the control group was higher than that in the low-dose group and high-dose group(P<0.05).Before surgery,the differences of Hb,HCT,PLT and FIB levels in the three groups were not significant(P>0.05);24 h postoperatively,the levels of Hb,HCT,PLT and FIB decreased in the three groups,and the decrease in the high-dose group was lower than that in the low-dose group and the control group(P<0.05).The differences of high cut whole blood viscosity,medium cut whole blood viscosity,low cut whole blood viscosity and plasma viscosity in the three groups before and 24 h after surgery were not significant compared with each other(P>0.05).Before surgery,there were no statistically significant differences in D-D and FDP levels among the three groups(P>0.05);24 hours after surgery,D-D and FDP in all three groups decreased,with the high-dose group being lower than the low-dose group and the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:High dose Tranexamic Acid has a significant effect in preventing postpartum hemorrhage after cesarean section.It can reduce intraoperative and postoperative bleeding,have minimal impact on coagulation function,regulate fibrinolysis function,stabilize blood rheology,and have high safety.
Different dosesTranexamic AcidCesareanPostpartum hemorrhageAntifibrinolysisCoagulation functionHemorheology
万方数据
维普
