Clinical Study on Tianzhi Granules Combined with Hyperbaric Oxygen in the Treatment of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
Objective:To explore the clinical efficacy of Tianzhi Granules combined with hyperbaric oxygen in the treatment of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP)and its effect on blood activating protein(AP)-1,nuclear factor-κB(NF-κB)and inflammatory factors.Method:From October 2018 to September 2022,60 patients with DEACMP disease admitted to Neurology of Tongliao City Hospital were selected and randomly divided into hyperbaric oxygen group and combined group,with 30 patients in each group.The hyperbaric oxygen group was treated with hyperbaric oxygen and conventional therapy,while the combined group received oral Tianzhi Granules treatment on the basis of the hyperbaric oxygen group,both groups were continued to receive treatment for 3 months.The clinical efficacy,recovery time of electroencephalography and disappearance time of neurological symptoms and signs of the two groups were observed,the scores of mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA),activities of daily living scale(ADL),serum interferon(IFN)-γ,interleukin(IL)-8,IL-10 content and activated protein(AP)-1,nuclear factor-κB(NF-κB)in peripheral blood mononuclear cell relative expression level were compared before and after treatment.Result:Compared with the hyperbaric oxygen group,the total effective rate in the combined group was significantly improved,the recovery time of electrograms and the disappearance time of symptoms and signs were shorter,the differences were statistically significant(P<0.05).Compared with before treatment,MMSE,MoCA,ADL scores were increased in both groups after treatment,and serum IFN-γ and IL-8 content were decreased,IL-10 content were increased,AP-1 and NF-κB in peripheral blood mononuclear cell were decreased,the differences were statistically significant(P<0.05);compared with the hyperbaric oxygen group after treatment,MMSE,MoCA,ADL scores were increased in the combined group,and serum IFN-γ,IL-8 levels were decreased,IL-10 was increased,and the relative expression of AP-1 and NF-κB in peripheral blood mononuclear cell were decreased,the differences were statistically significant(P<0.05).Conclusion:Tianzhi Granules combined with hyperbaric oxygen has good clinical effect in the treatment of DEACMP,and its mechanism may be related to the inhibition of inflammatory reaction.
Tianzhi GranulesHyperbaric oxygenDelayed encephalopathy after acute carbon monoxide poisoningInflammatory reaction
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维普
