Effect of Cefuroxime Axetil Combined with Xiaoer Chiqiao Qingre Granules in the Treatment of Upper Respiratory Tract Infection in Children
Objective:To investigate the clinical efficacy of Cefuroxime Axetil combined with Xiaoer Chiqiao Qingre Granules in the treatment of children with upper respiratory tract infection.Method:A total of 131 children with upper respiratory tract infection treated in Dangyang People's Hospital from November 2020 to November 2022 were selected and divided into control group(n=65)and observation group(n=66)by random number table method.The control group was treated with Cefuroxime Axetil,and the observation group was treated with Cefuroxime Axetil combined with Xiaoer Chiqiao Qingre Granules.The clinical symptom disappearance time,serum immunoglobulin[immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin E(IgE)],inflammatory indicators[C reactive protein(CRP),serum amyloid A(SAA),procalcitonin(PCT)],symptom score(fever,cough,nasal congestion),immune function indicators(CD3+,CD4+,CD8+,CD4+/CD8+)were compared between the two groups.Result:The disappearance time of fever,cough,sore throat and nasal congestion in control group were longer than those in observation group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in IgG,IgA,IgM and IgE between the two groups(P＞0.05);after treatment,IgE were decreased,IgG,IgA and IgM were increased in both groups,IgE in the observation group was lower than that in the control group,while IgG,IgA and IgM were higher than those in the control group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in CRP,SAA and PCT between the two groups(P＞0.05);after treatment,CRP,SAA and PCT were decreased in both groups,and the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in fever score,cough score and nasal congestion score between the two groups(P＞0.05);after treatment,the scores of fever,cough and nasal congestion in both groups were decreased,and the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in CD3+,CD4+,CD8+ and CD4+/CD8+ between the two groups(P＞0.05);after treatment,CD8+ decreased in both groups,while CD3+,CD4+ and CD4+/CD8+ increased in both groups,CD8+ in observation group was lower than that in control group,and CD3+,CD4+ and CD4+/CD8+ were higher than those in control group,the differences were statistically significant(P＜0.05).Conclusion:Cefuroxime Axetil combined with Xiaoer Chiqiao Qingre Granules has significant effect in the treatment of upper respiratory tract infection in children,which can improve the level of immunoglobulin,the expression levels of CRP,SAA and PCT,shorten the time of symptom disappearance and enhance the immune function of the body.
万方数据
维普
