Effects of 0.1 mg/kg Nalbuphine on Hemodynamics,Postoperative Pain and Chills of Parturiants Undergoing Cesarean Section under Combined Lumbo-epidural Anesthesia
Objective:To investigate the effects of 0.1 mg/kg Nalbuphine on hemodynamics,postoperative pain and chills of parturiants undergoing cesarean section under combined lumbo-epidural anesthesia.Method:A total of 100 pregnant women who planned to undergo cesarean section in Quanzhou First Hospital from April 2021 to April 2023 were selected as the research objects,combined lumbo-epidural anesthesia was adopted during the operation,random number table method was used to divide them into observation group and control group,50 cases in each group.The observation group was injected with 0.1 mg/kg Nalbuphine immediately after delivery after the umbilical cord was clip-on,the control group was injected with 0.9%Sodium Chloride Solution of equal volume.The hemodynamic indexes of the two groups were compared before anesthesia,immediately after medication,30 min and 6 h,Ramsay sedation score and visual analog scale(VAS)score of the two groups were compared,and the occurrence of chills and adverse reactions after medication were compared between the two groups.Result:Before anesthesia and immediately after medication,there were no significant differences in HR,MAP and SpO2 between the two groups(P＞0.05);compared with before anesthesia,HR,MAP and SpO2 in both groups were significantly decreased immediately after treatment(P＜0.05);compared with the immediate treatment,HR and MAP of the observation group had no statistical significance at 30 min and 6 h after treatment(P＞0.05),SpO2 were significantly increased(P＜0.05);in control group,HR and MAP were significantly increased(P＜0.05),while SpO2 had no statistical significance(P＞0.05);HR and MAP in observation group were lower than those of the control group,SpO2 were higher than those of control group at 30 min and 6 h(P＜0.05).Ramsay sedation score and VAS score in the observation group were better than those in the control group(P＜0.05).The incidence of chills in the observation group was better than that in the control group(P＜0.05).The incidence of adverse reactions was 8.00%in the observation group,which had no statistical significance compared with 14.00%in the control group(P＞0.05).Conclusion:Intravenous injection of 0.1 mg/kg Nalbuphine immediately after delivery of the fetus in cesarean section under combined lumbar and epidural anesthesia can maintain stable postpartum hemodynamics,further improve sedation and analgesia,effectively prevent and alleviate postoperative chills,and have less adverse drug reactions and high safety.
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维普
