Distribution Characteristics and Drug Tolerance Analysis of Common Pathogenic Bacteria in 208 Children in Pediatric Department of a Hospital
Objective:To investigate the distribution characteristics and drug tolerance analysis of common pathogenic bacteria in children in pediatric department of a hospital,and to provide data reference for the formulation of targeted antimicrobial agent therapy.Method:A total of 208 children's blood,sputum and feces samples collected from Longhua District Maternity&Child Healthcare Hospital from November 2022 to February 2023 were inoculated,cultured and separated.Drug susceptible test were conducted on 235 isolates of pathogenic bacteria,and the main pathogenic bacteria of infectious disease children and their drug tolerance to commonly used clinical antibiotics were analyzed.Result:A total of 235 strains of pathogenic bacteria were detected in the blood,sputum and feces samples of 208 children with infectious diseases.The main pathogenic bacteria of pediatric infectious disease was Gram negative bacterium,accounting for 73.62%(173/235),among which Haemophilus influenzae(43.40%)accounted for the highest proportion,followed by Moraxella catarrhalis(15.32%)and Klebsiella pneumoniae(8.94%).Haemophilus influenzae in Gram negative bacterium had no drug tolerance to carbapenems antimicrobial agent,and the drug tolerance to Cefuroxime was the highest,with 76.47%.Moraxella catarrhalis had no drug tolerance to Ciproxacin,Aztreonam and antimicrobial agent of aminoglycoside and carbapenems,and the drug tolerance to Cefuroxime was the highest,with 72.22%.Klebsiella pneumoniae showed relatively high drug tolerance to many kinds of cephalosporin antimicrobial agent.Streptococcal pneumoniae in Gram positive bacterium was up to 100%drug tolerance to Clindamycin,while Staphylococcus aureus was 100%drug tolerance to Penicillin.Conclusion:Gram negative bacterium are the main pathogenic bacteria in children with infectious diseases,and the isolated common pathogenic bacteria,such as Haemophilus influenzae,Moraxella catarrhalis,Klebsiella pneumoniae and Staphylococcus aureus,have multidrug resistant.Haemophilus influenzae is the main pathogenic bacteria that causes children with infectious diseases.
Department of pediatricsPathogenic bacteriaDistribution characteristicsDrug tolerance
万方数据
维普
