Application Effect of Different Injection Methods of Dexmedetomidine Combined with General Anesthesia in Laparoscopic Hysterectomy
Objective:To explore the efficacy and safety of different injection methods of Dexmedetomidine combined with general anesthesia in laparoscopic hysterectomy.Method:A total of 92 patients undergoing laparoscopic hysterectomy admitted to Tianjin Dongli Hospital from October 2020 to October 2022 were selected,group A(n=32)received general anesthesia,group B(n=30)received continuous pump Dexmedetomidine,and group C(n=30)received a single injection of Dexmedetomidine.The hemodynamic levels,blood glucose and fibrinolytic system indexes,stress response after entry(T0),5 min after anesthesia(T1),tracheal intubation(T2),immediately after surgery(T3),24 h after surgery(T4),anesthesia effect and adverse reactions of the three groups were compared.Result:Compared with T0,HR and MAP of T1,T2,T3 and T4 in the three groups were all increased,and HR and MAP of T1,T2,T3 and T4 in group C were lower than those in group B and group A,and those in group B were lower than those in group A(P＜0.05).The blood glucose levels,D-D,PAI-1 and t-PA at T2,T3,T4 in group C were lower than those in group B and group A,and those in group B were lower than those in group A(P＜0.05).The recovery time of spontaneous respiration,extubation time and recovery time of group C were earlier than those of group B and group A,and those in group B were earlier than those in group A(P＜0.05).The incidence of adverse reactions among the three groups was statistically significant(X2=8.276,P=0.002);the incidence of adverse reactions in group A(37.50%)and group B(26.67%)were higher than that in group C(6.67%)(P＜0.05).Conclusion:Single injection of Dexmedetomidine in laparoscopic hysterectomy has significant anesthetic effect,can stabilize the hemodynamics of patients,has little impact on the fibrinolytic system of patients,reduces stress response,and is safe.
DexmedetomidineDifferent injection methodsCompound general anesthesiaLaparoscopic hysterectomySafety
万方数据
维普
